Hermetically Packaged Microsensor for Quality Factor-Enhanced Photoacoustic Biosensing.
Biosensing
Micromechanical resonator
Photoacoustics
Quality factor
Vacuum-packaged
Journal
Photoacoustics
ISSN: 2213-5979
Titre abrégé: Photoacoustics
Pays: Germany
ID NLM: 101622604
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
21
09
2019
revised:
29
03
2020
accepted:
29
04
2020
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
2
6
2020
Statut:
epublish
Résumé
The use of photoacoustics (PA) being a convenient non-invasive analysis tool is widespread in various biomedical fields. Despite significant advances in traditional PA cell systems, detection platforms capable of providing high signal-to-noise ratios and steady operation are yet to be developed for practical micro/nano biosensing applications. Microfabricated transducers offer orders of magnitude higher quality factors and greatly enhanced performance in extremely miniature dimensions that is unattainable with large-scale PA cells. In this work we exploit these attractive attributes of microfabrication technology and describe the first implementation of a vacuum-packaged microscale resonator in photoacoustic biosensing. Steady operation of this functional approach is demonstrated by detecting the minuscule PA signals from the variations of trace amounts of glucose in gelatin-based synthetic tissues. These results demonstrate the potential of the novel approach to broad photoacoustic applications, spanning from micro-biosensing modules to the analysis of solid and liquid analytes of interest in condense mediums.
Identifiants
pubmed: 32477865
doi: 10.1016/j.pacs.2020.100189
pii: S2213-5979(20)30029-X
pii: 100189
pmc: PMC7248651
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100189Informations de copyright
© 2020 The Author(s).
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