Washout Period for Pregnancy Post Isotretinoin Therapy.
Contraception
India
isotretinoin
new guidelines
pregnancy
Journal
Indian dermatology online journal
ISSN: 2229-5178
Titre abrégé: Indian Dermatol Online J
Pays: India
ID NLM: 101586880
Informations de publication
Date de publication:
Historique:
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
2
6
2020
Statut:
epublish
Résumé
Isotretinoin is an oral medication used for the treatment of severe acne unresponsive to other medications. This drug is teratogenic and should be prescribed with appropriate caution in selected group of patients. The washout period for pregnancy post isotrenoin therapy has always been a topic of controversy. Several guidelines have recommended a wash out period of one month if pregnancy is planned in a patient being administered with the drug. This article discusses the available evidence for different recommended wash out periods and addresses important clinical questions that arise. Pubmed research was carried out to collect relevant data using the keywords isotretinoin, pregnancy, contraception, pharmacokinetics and guidelines. Our research based on the published data concludes that a wash out period of 35 days post isotretinoin therapy is adequate in routine clinical practice.
Sections du résumé
INTRODUCTION AND BACKGROUND
BACKGROUND
Isotretinoin is an oral medication used for the treatment of severe acne unresponsive to other medications. This drug is teratogenic and should be prescribed with appropriate caution in selected group of patients. The washout period for pregnancy post isotrenoin therapy has always been a topic of controversy. Several guidelines have recommended a wash out period of one month if pregnancy is planned in a patient being administered with the drug.
OBJECTIVE
OBJECTIVE
This article discusses the available evidence for different recommended wash out periods and addresses important clinical questions that arise.
METHODS
METHODS
Pubmed research was carried out to collect relevant data using the keywords isotretinoin, pregnancy, contraception, pharmacokinetics and guidelines.
CONCLUSION
CONCLUSIONS
Our research based on the published data concludes that a wash out period of 35 days post isotretinoin therapy is adequate in routine clinical practice.
Identifiants
pubmed: 32477989
doi: 10.4103/idoj.IDOJ_101_19
pii: IDOJ-11-239
pmc: PMC7247620
doi:
Types de publication
Journal Article
Langues
eng
Pagination
239-242Informations de copyright
Copyright: © 2020 Indian Dermatology Online Journal.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Arch Biochem Biophys. 1993 Feb 1;300(2):751-5
pubmed: 8382035
J Am Acad Dermatol. 1998 Aug;39(2 Pt 3):S8-12
pubmed: 9703117
Dermatology. 1996;193(2):124-6
pubmed: 8884148
PLoS Med. 2006 Nov;3(11):e483
pubmed: 17121451
Eur J Clin Pharmacol. 1983;24(5):695-702
pubmed: 6575917
J Invest Dermatol. 2006 Oct;126(10):2178-89
pubmed: 16575387
Arch Dermatol. 1989 Mar;125(3):362-5
pubmed: 2923442
N Engl J Med. 1998 Apr 16;338(16):1128-37
pubmed: 9545362
Br J Clin Pharmacol. 2009 Jan;67(1):137-8
pubmed: 19076160
Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4
pubmed: 8380496
J Am Acad Dermatol. 1996 Mar;34(3):513-5
pubmed: 8609271
Yonsei Med J. 2009 Jun 30;50(3):445-7
pubmed: 19568610
Dermatoendocrinol. 2009 May;1(3):162-9
pubmed: 20436884
J Clin Pharmacol. 1998 Oct;38(10):926-30
pubmed: 9807973
Arch Dermatol. 2005 May;141(5):563-9
pubmed: 15897377
CMAJ. 2013 Mar 19;185(5):411-3
pubmed: 23296582
J Am Acad Dermatol. 1982 Apr;6(4 Pt 2 Suppl):643-51
pubmed: 6461675
Can Fam Physician. 2006 Mar;52:338-9
pubmed: 16926960
J Eur Acad Dermatol Venereol. 2006 Aug;20(7):773-6
pubmed: 16898895
N Engl J Med. 1989 Apr 13;320(15):1007-9
pubmed: 2522591
J Clin Pharmacol. 1982 Aug-Sep;22(8-9):395-402
pubmed: 6957421
J Invest Dermatol. 2000 Aug;115(2):321-7
pubmed: 10951254