Sindbis Virus with Anti-OX40 Overcomes the Immunosuppressive Tumor Microenvironment of Low-Immunogenic Tumors.
Sindbis
alpha-virus immunotherapy
anti-OX40
anti-tumor immunity
cancer immunity
oncolytic virus anti-OX40 combination therapy
Journal
Molecular therapy oncolytics
ISSN: 2372-7705
Titre abrégé: Mol Ther Oncolytics
Pays: United States
ID NLM: 101666776
Informations de publication
Date de publication:
26 Jun 2020
26 Jun 2020
Historique:
received:
15
04
2020
accepted:
29
04
2020
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
2
6
2020
Statut:
epublish
Résumé
Despite remarkable responses to cancer immunotherapy in a subset of patients, many patients remain resistant to therapies. It is now clear that elevated levels of tumor-infiltrating T cells as well as a systemic anti-tumor immune response are requirements for successful immunotherapies. However, the tumor microenvironment imposes an additional resistance mechanism to immunotherapy. We have developed a practical and improved strategy for cancer immunotherapy using an oncolytic virus and anti-OX40. This strategy takes advantage of a preexisting T cell immune repertoire
Identifiants
pubmed: 32478167
doi: 10.1016/j.omto.2020.04.012
pii: S2372-7705(20)30062-0
pmc: PMC7251545
doi:
Types de publication
Journal Article
Langues
eng
Pagination
431-447Subventions
Organisme : NCI NIH HHS
ID : R44 CA250627
Pays : United States
Informations de copyright
© 2020 The Author(s).
Références
Science. 2016 Oct 28;354(6311):481-484
pubmed: 27708054
J Natl Cancer Inst. 2002 Dec 4;94(23):1790-802
pubmed: 12464651
Front Oncol. 2017 Apr 12;7:68
pubmed: 28447025
Sci Transl Med. 2018 Jan 31;10(426):
pubmed: 29386357
Genome Biol. 2010;11(10):R106
pubmed: 20979621
Curr Immunol Rev. 2005 Jun;1(2):119-137
pubmed: 21037949
Cell. 2017 Jan 26;168(3):487-502.e15
pubmed: 28111070
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Mol Ther Oncolytics. 2018 May 03;9:51-63
pubmed: 29988525
Nat Rev Clin Oncol. 2019 Jul;16(7):425-441
pubmed: 30914826
J Virol. 1993 Nov;67(11):6439-46
pubmed: 8411346
Cell. 2015 Sep 10;162(6):1229-41
pubmed: 26321679
Ann Oncol. 2004 Jun;15(6):988-9
pubmed: 15151960
Parasitol Int. 2012 Mar;61(1):124-9
pubmed: 21820080
Immunity. 2016 Sep 20;45(3):701-703
pubmed: 27653602
J Exp Med. 2012 Aug 27;209(9):1671-87
pubmed: 22908323
J Clin Oncol. 2015 Sep 1;33(25):2780-8
pubmed: 26014293
PLoS One. 2018 Nov 2;13(11):e0206223
pubmed: 30388137
J Immunol. 2008 Dec 15;181(12):8576-84
pubmed: 19050277
Genome Biol. 2009;10(3):R25
pubmed: 19261174
Science. 2006 Sep 29;313(5795):1960-4
pubmed: 17008531
Cancer Immunol Res. 2016 Dec;4(12):1001-1006
pubmed: 27908931
Cancer Immunol Immunother. 2011 Oct;60(10):1419-30
pubmed: 21644036
Cell. 2012 May 25;149(5):979-93
pubmed: 22608084
Oncotarget. 2017 May 31;8(60):102617-102639
pubmed: 29254276
Nat Genet. 2006 May;38(5):500-1
pubmed: 16642009
Cell Rep. 2013 Jan 31;3(1):246-59
pubmed: 23318258
Cell. 2017 Sep 7;170(6):1120-1133.e17
pubmed: 28803728
Nat Immunol. 2016 Jan;17(1):95-103
pubmed: 26523864
Med Res Rev. 2019 Jan;39(1):70-113
pubmed: 29785785
Gene Ther. 2012 Oct;19(10):988-98
pubmed: 22071969
Mol Ther. 2014 Jan;22(1):112-22
pubmed: 24025748
Oncol Lett. 2016 Sep;12(3):1941-1948
pubmed: 27588143
Immunity. 2007 Aug;27(2):281-95
pubmed: 17723218
Gynecol Oncol. 2012 Feb;124(2):192-8
pubmed: 22040834
PLoS One. 2011;6(6):e20598
pubmed: 21674047
PLoS One. 2010 Nov 15;5(11):e13984
pubmed: 21085593
Nat Commun. 2011;2:240
pubmed: 21407206
Clin Cancer Res. 2010 May 15;16(10):2861-71
pubmed: 20460488
J Exp Med. 2018 Apr 2;215(4):1091-1100
pubmed: 29511066
Cell Rep. 2018 Jul 17;24(3):607-618
pubmed: 30021159
Immunity. 2016 Aug 16;45(2):233-5
pubmed: 27533009
J Immunother. 2013 Nov-Dec;36(9):477-89
pubmed: 24145359
Nat Immunol. 2013 Mar;14(3):281-9
pubmed: 23334788
Science. 1993 Apr 23;260(5107):547-9
pubmed: 8097338
Sci Transl Med. 2014 Mar 5;6(226):226ra32
pubmed: 24598590
Immunity. 2012 Mar 23;36(3):374-87
pubmed: 22425248
Nat Immunol. 2013 Mar;14(3):271-80
pubmed: 23334789
Carcinogenesis. 1993 Nov;14(11):2353-8
pubmed: 8242866
Eur J Cancer. 2016 Jan;52:50-66
pubmed: 26645943
Exp Cell Res. 2011 Mar 10;317(5):620-31
pubmed: 21376175
Cell. 2015 Sep 10;162(6):1217-28
pubmed: 26321681
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
J Immunother Cancer. 2018 Dec 27;6(1):157
pubmed: 30587233
Nat Genet. 2003 Jul;34(3):267-73
pubmed: 12808457
Carcinogenesis. 2004 Sep;25(9):1771-8
pubmed: 15105299
Ann Surg Oncol. 2006 Aug;13(8):1078-84
pubmed: 16865590
Cancer Immunol Res. 2017 Jan;5(1):9-16
pubmed: 27941003
Eur J Immunol. 2005 Nov;35(11):3297-306
pubmed: 16220539
Science. 2013 Oct 11;342(6155):1242454
pubmed: 24115444
Cancer Res. 2011 Aug 15;71(16):5445-54
pubmed: 21708958
Blood. 2004 Apr 15;103(8):3065-72
pubmed: 15070686
Cancer Res. 2016 Jul 1;76(13):3684-9
pubmed: 27197182
Cancer Gene Ther. 2011 Mar;18(3):167-75
pubmed: 21102422
Nat Rev Drug Discov. 2019 Mar;18(3):197-218
pubmed: 30610226
Trends Immunol. 2015 Apr;36(4):257-64
pubmed: 25773310
Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a001008
pubmed: 20182602
Nat Biotechnol. 2004 Jan;22(1):70-7
pubmed: 14647305
PLoS Pathog. 2012 Sep;8(9):e1002913
pubmed: 22969431
Vaccines (Basel). 2016 Dec 06;4(4):
pubmed: 27929420
Biochim Biophys Acta. 1970 Dec 29;222(3):565-82
pubmed: 5496487
Mol Ther. 2012 Feb;20(2):298-305
pubmed: 22068428
Cancer Res. 2004 Sep 15;64(18):6684-92
pubmed: 15374985
Cell. 2018 Aug 9;174(4):1031-1032
pubmed: 30096300
Cancer Immunol Res. 2013 Oct;1(4):229-34
pubmed: 24777852
Cell Immunol. 2010;262(2):89-95
pubmed: 20236628
J Virol. 1992 Aug;66(8):4992-5001
pubmed: 1385835
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2729-34
pubmed: 19202079
Nat Rev Cancer. 2012 Mar 22;12(4):252-64
pubmed: 22437870
Cancer Res. 2017 Jul 15;77(14):3894-3907
pubmed: 28566332
J Exp Med. 2011 Mar 14;208(3):469-78
pubmed: 21339327
Cell. 2000 Mar 17;100(6):655-69
pubmed: 10761931
J Exp Med. 2015 Aug 24;212(9):1345-60
pubmed: 26261266
Cancer Gene Ther. 2012 Nov;19(11):757-66
pubmed: 22956041
Nat Biotechnol. 2019 Jan 3;37(1):12-17
pubmed: 30605149
J Immunol. 2008 May 1;180(9):5935-45
pubmed: 18424713
Clin Cancer Res. 2010 Jul 1;16(13):3485-94
pubmed: 20479064
Melanoma Res. 2016 Oct;26(5):429-41
pubmed: 27455380
Clin Transl Med. 2018 Nov 14;7(1):35
pubmed: 30426287
Immunology. 2017 Oct;152(2):175-184
pubmed: 28621843
Nat Genet. 2019 Feb;51(2):202-206
pubmed: 30643254
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
Science. 2015 Apr 3;348(6230):56-61
pubmed: 25838373
J Immunother Cancer. 2018 May 16;6(1):36
pubmed: 29764498