Potent HCV NS3 Protease Inhibition by a Water-Soluble Phyllanthin Congener.


Journal

ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658

Informations de publication

Date de publication:
26 May 2020
Historique:
received: 22 02 2020
accepted: 30 04 2020
entrez: 2 6 2020
pubmed: 2 6 2020
medline: 2 6 2020
Statut: epublish

Résumé

NS3/4A protease of hepatitis C virus (HCV) plays an important role in viral RNA replication. A 1,4-diphenylbutanedicarboxylic acid derivative, namely, phyllanthin, extracted from the leaf of a herbal plant,

Identifiants

pubmed: 32478245
doi: 10.1021/acsomega.0c00786
pmc: PMC7254805
doi:

Types de publication

Journal Article

Langues

eng

Pagination

11553-11562

Informations de copyright

Copyright © 2020 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Uma Reddy B (UR)

Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India.

Himani Tandon (H)

Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.

Manoj K Pradhan (MK)

Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.

Harikrishnan Adhikesavan (H)

Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.

Narayanaswamy Srinivasan (N)

Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.

Saumitra Das (S)

Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India.
National Institute of Biomedical Genomics, Kalyani 741 251, India.

Narayanaswamy Jayaraman (N)

Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.

Classifications MeSH