Supplementation of nanofiltrated deep ocean water ameliorate the progression of osteoporosis in ovariectomized rat via regulating osteoblast differentiation.
bone adiposity
deep ocean water
magnesium
menopause
osteoporosis
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
09
10
2019
revised:
03
03
2020
accepted:
16
03
2020
pubmed:
2
6
2020
medline:
22
6
2021
entrez:
2
6
2020
Statut:
ppublish
Résumé
Magnesium was reported to be necessary for bone formation. Previous study indicated nanofiltrated deep ocean water (DOW) rich in magnesium. This study investigated the potential mechanisms of DOW in ameliorating osteoporosis. Briefly, female Sprague-Dawley rat was ovariectomized and fed with 0.35, 0.7, or 1.4 ml/kg of DOW daily for 8 weeks. In the results, DOW increased bone density, decreased trabecular bone loss, and decreased bone adiposity. DOW improved bone mass by examining structure in micro-computed tomography. About 0.35 and 0.7 ml/kg of DOW can increase protein expression of runt-related transcription factor 2 (RUNX2), an essential transcription factor for regulating osteoblast differentiation, by 9.4% or 12.9%. In human osteoblast, DOW increased the levels of osteocalcin, RUNX2, and alkaline phosphatase; all the proteins can regulate osteoblast differentiation. Considering the results of in vivo and in vitro study, DOW can ameliorate ovareictomy-caused osteoporosis via regulating the osteoblast differentiation, thereby, maintenance of bone structure. PRACTICAL APPLICATIONS: In addition to calcium, magnesium is essential to promoting the deposition of calcium in bones and regulating its transport; it may also slow the progression of osteoporosis. Nanofiltrated DOW contains abundant magnesium along with several microelements and peptides. In this study, a product was developed for decelerating osteoporosis by using an estrogen depletion model. DOW regulates osteoblast differentiation and thus prevents osteoporosis. This finding provides an alternative healthy source of bone supplements. In addition to tablets or capsules, aqueous supplements can be produced to achieve osteoporosis prevention. This finding is beneficial to the health-care industry for developing sustainable supplements.
Substances chimiques
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13236Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Aaseth, J., Boivin, G., & Andersen, O. (2012). Osteoporosis and trace elements - An overview. Journal of Trace Elements in Medicine and Biology, 26, 149-152. https://doi.org/10.1016/j.jtemb.2012.03.017
Abdallah, B. M., Al-Shammary, A., Khatta, H. M., AlDahmash, A., & Kassem, M. (2016). Bone marrow stromal stem cells for bone repair: Basic and translational aspects. In E. Abdelalim (Ed.), Recent advances in stem cells. Stem cell biology and regenerative medicine (pp. 213-232). Cham: Humana Press.
Galli, S., Stocchero, M., Andersson, M., Karlsson, J., He, W., Lilin, T., … Jimbo, R. (2017). The effect of magnesium on early osseointegration in osteoporotic bone: A histological and gene expression investigation. Osteoporosis International, 28, 2195-2205. https://doi.org/10.1007/s00198-017-4004-5
Grigoryan, A. V., Dimitrova, A. A., Kostov, K. G., Russeva, A. L., Atanasova, M. A., Blagev, A. B., … Trifonov, R. G. (2017). Changes of serum concentrations of alkaline phosphatase and metalloproteinase-9 in an ovariectomized wistar rat model of osteoporosis. Journal of Biomedical and Clinical Research, 10, 32-36. https://doi.org/10.1515/jbcr-2017-0006
Guo, Y., Ren, L., Liu, C., Yuan, Y., Lin, X., Tan, L., … Mei, X. (2013). Effect of implantation of biodegradable magnesium alloy on BMP-2 expression in bone of ovariectomized osteoporosis rats. Material Science and Engineering Technology: C, 33, 4470-4474. https://doi.org/10.1016/j.msec.2013.05.042
Ha, B., Shin, E., Park, J.-E., & Shon, Y. (2013). Anti-diabetic effect of balanced deep-sea water and its mode of action in high-fat diet induced diabetic mice. Marine Drugs, 11, 4193-4212. https://doi.org/10.3390/md11114193
He, L. Y., Zhang, X. M., Liu, B., Tian, Y., & Ma, W. H. (2016). Effect of magnesium ion on human osteoblast activity. Brazilian Journal of Medical and Biological Research, 49, https://doi.org/10.1590/1414-431X20165257
Huang, J. H., Cheng, F. C., & Wu, H. C. (2015). Low magnesium exacerbates osteoporosis in chronic kidney disease patients with diabetes. International Journal of Endocrinology, 10, https://doi.org/10.1155/2015/380247
Karaaslan, F., Mutlu, M., Mermerkaya, M. U., Karaoğlu, S., Saçmaci, S., & Kartal, S. (2014). Comparison of bone tissue trace-elementconcentrations and mineral density in osteoporotic femoral neck fractures and osteoarthritis. Clinical Intervention in Aging, 9, 1375-1382.
Liu, H. Y., Liu, M. C., Wang, M. F., Chen, W. H., Tsai, C. Y., Wu, K. H., … Deng, W. P. (2013). Potential osteoporosis recovery by deep sea water through bone regeneration in SAMP8 mice. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2013/161976
Mahdavi-Roshan, M., Ebrahimi, M., & Ebrahimi, A. (2015). Copper, magnesium, zinc and calcium status in osteopenic and osteoporotic post-menopausal women. Clinical Cases in Mineral and Bone Metabolism, 12, 18-21. https://doi.org/10.11138/ccmbm/2015.12.1.018
Miyamura, M., Yoshioka, S., Hamada, A., Takuma, D., Yokota, J., Kusunose, M., … Nishioka, Y. (2004). Difference between deep seawater and surface seawater in the preventive effect of atherosclerosis. Biological and Pharmaceutical Bulletin, 27, 1784-1787. https://doi.org/10.1248/bpb.27.1784
Nakamura, T., Nakamura-Takahashi, A., Kasahara, M., Yamaguchi, A., & Azuma, T. (2020). Tissue-nonspecific alkaline phosphatase promotes the osteogenic differentiation of osteoprogenitor cells. Biochemical and Biophysical Research Communications, 524, 702-709. https://doi.org/10.1016/j.bbrc.2020.01.136
Orchard, T. S., Larson, J. C., Alghothani, N., Bout-Tabaku, S., Cauley, J. A., Chen, Z., … Jackson, R. D. (2014). Magnesium intake, bone mineral density, and fractures: Results from the Women’s Health Initiative Observational Study. The American Journal of Clinical Nutrition, 99, 926-933. https://doi.org/10.3945/ajcn.113.067488
Rude, R. K., Gruber, H. E., Wei, L. Y., Frausto, A., & Mills, B. G. (2003). Magnesium deficiency: Effect on bone and mineral metabolism in the mouse. Calcified Tissue International, 72, 32-41. https://doi.org/10.1007/s00223-001-1091-1
Sebastian, E. S., & Kenneth, G. S. (2014). Fracture mortality: Associations with epidemiology and osteoporosis treatment. Nature Reviews Endocrinology, 10, S7-S15.
Sukumaran, S. (2015). A comparative study of serum calcium, magnesium and its ratio in women of menopausal and reproductive age group. International Journal of Research in Medical Sciences, 3, 2024-2028. https://doi.org/10.18203/2320-6012.ijrms20150320
Vennin, S., Desyatova, A., Turner, J. A., Watson, P. A., Lappe, J. M., Recker, R. R., & Akhter, M. P. (2017). Intrinsic material property differences in bone tissue from patients suffering low-trauma osteoporotic fractures, compared to matched non-fracturing women. Bone, 97, 233-242. https://doi.org/10.1016/j.bone.2017.01.031
Zofkova, I., Davis, M., & Blahos, J. (2017). Trace elements have beneficial, as well as detrimental effects on bone homeostasis. Physiological Research, 66, 391-402. https://doi.org/10.33549/physiolres.933454