Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort.
Chronic hypertension
endothelium
kidney
placenta
superimposed preeclampsia
Journal
Hypertension in pregnancy
ISSN: 1525-6065
Titre abrégé: Hypertens Pregnancy
Pays: England
ID NLM: 9421297
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
pubmed:
2
6
2020
medline:
28
5
2021
entrez:
2
6
2020
Statut:
ppublish
Résumé
To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension. Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls. Syndecan-1 concentrations were lower at 26-27 Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.
Identifiants
pubmed: 32479208
doi: 10.1080/10641955.2020.1769643
doi:
Substances chimiques
Biomarkers
0
Cystatin C
0
Lipocalin-2
0
PGF protein, human
0
Placenta Growth Factor
144589-93-5
Vascular Endothelial Growth Factor Receptor-1
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
326-335Subventions
Organisme : Department of Health
ID : RP-2014-05-019
Pays : United Kingdom