Small for gestational age-cognitive performance from infancy to adulthood: an observational study.
Cognition
IQ
cognitive development
growth restriction
small for gestational age
term
very preterm
Journal
BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
accepted:
21
05
2020
pubmed:
2
6
2020
medline:
15
12
2020
entrez:
2
6
2020
Statut:
ppublish
Résumé
To determine whether cognitive performance from infancy to adulthood is affected by being born small for gestational age (SGA), and if this depends on the SGA reference used. Furthermore, to determine SGA's effect while considering the effects of very preterm/very low birthweight (VP/VLBW), socio-economic status (SES) and parent-infant relationship. A total of 414 participants (197 term-born, 217 VP/VLBW) of the Bavarian Longitudinal Study. Small for gestational age was classified using neonatal or fetal growth references. SES and the parent-infant relationship were assessed before the infant was 5 months old. Developmental (DQ) and intelligence (IQ) tests assessed cognitive performance on six occasions, from 5 months to 26 years of age. The fetal reference classified more infants as SGA (<10th centile) than the neonatal reference (n = 138, 33% versus n = 75, 18%). Using linear mixed models, SGA was associated with IQ -8 points lower than appropriate for gestational age, regardless of reference used (95% CI -13.66 to -0.64 and 95% CI -13.75 to -1.98). This difference narrowed minimally into adulthood. Being VP/VLBW was associated with IQ -16 (95% CI -21.01 to -10.04) points lower than term-born participants. Low SES was associated with IQ -14 (95% CI -18.55 to -9.06) points lower than high SES. A poor parent-infant relationship was associated with IQ -10 points lower than those with a good relationship (95% CI -13.91 to -6.47). Small for gestational age is associated with lower IQ throughout development, independent of VP/VLBW birth, low SES or poor parent-child relationship. Social factors effects on IQ comparable to those of SGA and should be considered for interventions. Small for gestational age is associated with lower cognitive performance from infancy to adulthood.
Identifiants
pubmed: 32479707
doi: 10.1111/1471-0528.16341
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1598-1606Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 01EP9504
Pays : International
Organisme : Bundesministerium für Bildung und Forschung
ID : 01ER0801
Pays : International
Organisme : Bundesministerium für Bildung und Forschung
ID : JUG14
Pays : International
Organisme : Bundesministerium für Bildung und Forschung
ID : PKE24
Pays : International
Organisme : Horizon 2020 Framework Programme
ID : 733280
Pays : International
Informations de copyright
© 2020 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists.
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