Filoviruses Infect Rhesus Macaque Synoviocytes in Vivo and Primary Human Synoviocytes in Vitro.
Journal
The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
21
01
2020
revised:
05
05
2020
accepted:
08
05
2020
pubmed:
2
6
2020
medline:
22
9
2020
entrez:
2
6
2020
Statut:
ppublish
Résumé
The most commonly reported symptom of post-Ebola virus disease syndrome in survivors is arthralgia, yet involvement of the joints in acute or convalescent Ebola virus infection is not well characterized in human patients or animal models. Through immunohistochemistry, we found that the lining synovial intima of the stifle (knee) is a target for acute infection by Ebola virus/Kikwit, Ebola virus/Makona-C05, and Marburg virus/Angola in the rhesus macaque model. Furthermore, histologic analysis, immunohistochemistry, RNAscope in situ hybridization, and transmission electron microscopy showed that synoviocytes of the stifle, shoulder, and hip are a target for mouse-adapted Ebola virus/Yambuku-Mayinga infection during acute disease in rhesus macaques. A time course of infection study with Ebola virus/Kikwit found that the large joint synovium became immunopositive beginning on postinfection day 6. In total, the synovium of 28 of 30 rhesus macaques with terminal filovirus disease had evidence of infection (64 of 96 joints examined). On the basis of immunofluorescence, infected cell types included CD68
Identifiants
pubmed: 32479821
pii: S0002-9440(20)30256-X
doi: 10.1016/j.ajpath.2020.05.013
pmc: PMC7456742
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1867-1880Subventions
Organisme : NCI NIH HHS
ID : 75N91019D00024
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201500003C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201500003I
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272200700016I
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Références
J Infect Dis. 2018 Nov 22;218(suppl_5):S423-S433
pubmed: 30053050
Klin Wochenschr. 1968 Apr 1;46(7):398-400
pubmed: 4971902
PLoS Pathog. 2017 Mar 9;13(3):e1006219
pubmed: 28278237
J Clin Invest. 2010 Mar;120(3):894-906
pubmed: 20179353
Lab Med. 2019 Jan 1;50(1):16-28
pubmed: 30085179
Open Rheumatol J. 2011;5:100-6
pubmed: 22279508
Microcirculation. 1995 Sep;2(3):217-33
pubmed: 8748946
J Pathol. 2015 Jan;235(2):153-74
pubmed: 25297522
Sci Rep. 2017 Jul 19;7(1):5886
pubmed: 28725019
Emerg Infect Dis. 2016 Jan;22(1):150-2
pubmed: 26690042
Immunol Rev. 2010 Jan;233(1):233-55
pubmed: 20193003
Curr Opin Pharmacol. 2013 Aug;13(4):565-9
pubmed: 23611654
Viruses. 2019 Feb 16;11(2):
pubmed: 30781518
Sci Rep. 2017 Feb 09;7:42147
pubmed: 28181533
N Engl J Med. 1985 Oct 31;313(18):1117-23
pubmed: 4047116
Clin Podiatr Med Surg. 2018 Jul;35(3):281-293
pubmed: 29861012
J Infect Dis. 1999 Feb;179 Suppl 1:S1-7
pubmed: 9988155
J Infect Dis. 2016 Oct 15;214(suppl 3):S177-S184
pubmed: 27443613
Clin Infect Dis. 2016 Nov 15;63(10):1353-1356
pubmed: 27585800
J Surg Res. 1995 May;58(5):478-84
pubmed: 7745959
Arch Histol Cytol. 2000 Mar;63(1):17-31
pubmed: 10770586
Lancet Infect Dis. 2018 Jul;18(7):738-748
pubmed: 29627147
J Infect Dis. 1999 Feb;179 Suppl 1:S28-35
pubmed: 9988162
Clin Infect Dis. 2015 Oct 1;61(7):1035-42
pubmed: 26060289
Clin Infect Dis. 2016 Jun 1;62(11):1360-1366
pubmed: 27001797
Clin Infect Dis. 2019 Nov 06;:
pubmed: 31693114
Nat Rev Microbiol. 2019 May;17(5):261-263
pubmed: 30926957
Clin Exp Rheumatol. 2018 May-Jun;36(3):494-501
pubmed: 29533749
J Infect Dis. 2015 Oct 1;212 Suppl 2:S119-28
pubmed: 26209681
Clin Infect Dis. 2019 Nov 30;:
pubmed: 31784751
N Engl J Med. 2015 Jun 18;372(25):2423-7
pubmed: 25950269
Rheumatology (Oxford). 2017 Dec 1;56(12):2068-2072
pubmed: 28371810
Rheumatology (Oxford). 2008 Aug;47(8):1137-43
pubmed: 18390894
Nat Microbiol. 2017 Jul 17;2:17113
pubmed: 28715405
Folia Biol (Praha). 2011;57(3):119-24
pubmed: 21888835
Lancet Infect Dis. 2016 Mar;16(3):331-8
pubmed: 26725449
N Engl J Med. 2019 Mar 7;380(10):924-934
pubmed: 30855742
Joint Bone Spine. 2015 Dec;82(6):394-6
pubmed: 26190455
Cell Host Microbe. 2018 Sep 12;24(3):405-416.e3
pubmed: 30173956
J Infect Dis. 2017 Jun 15;215(12):1789-1798
pubmed: 28549145
Arch Pathol Lab Med. 2001 May;125(5):625-30
pubmed: 11300932
Clin Infect Dis. 2015 Dec 1;61(11):1648-54
pubmed: 26179011
Am J Pathol. 2018 Mar;188(3):550-558
pubmed: 29429544
BMJ. 2015 Jul 14;351:h3443
pubmed: 26175053
J Comp Pathol. 2001 Nov;125(4):243-53
pubmed: 11798241
Lancet Infect Dis. 2015 Aug;15(8):905-12
pubmed: 25910637
Arch Pathol Lab Med. 1997 Aug;121(8):805-19
pubmed: 9278608
Clin Infect Dis. 2016 Jan 1;62(1):125-6
pubmed: 26349549
Rheumatology (Oxford). 2018 Jan 1;57(1):28-31
pubmed: 28379487
J Infect Dis. 2018 May 18;217(suppl_1):S6-S15
pubmed: 29788345
Lancet. 2016 Jul 30;388(10043):498-503
pubmed: 27209148
Emerg Infect Dis. 2010 Dec;16(12):1969-72
pubmed: 21122234
Expert Rev Vaccines. 2018 Dec;17(12):1105-1110
pubmed: 30422031
APMIS. 2010 Sep 1;118(9):665-73
pubmed: 20718718