In utero and lactational exposure to triclocarban: Age-associated changes in reproductive parameters of male rat offspring.
Age Factors
Animals
Anti-Infective Agents, Local
/ toxicity
Carbanilides
/ toxicity
Female
Lactation
/ drug effects
Male
Pregnancy
Prenatal Exposure Delayed Effects
/ blood
Rats
Rats, Wistar
Reproduction
/ drug effects
Sexual Behavior, Animal
/ drug effects
Testis
/ drug effects
Testosterone
/ blood
Endocrine disruptor
Hypothalamic sexual differentiation
Personal care product
Journal
Toxicology and applied pharmacology
ISSN: 1096-0333
Titre abrégé: Toxicol Appl Pharmacol
Pays: United States
ID NLM: 0416575
Informations de publication
Date de publication:
15 08 2020
15 08 2020
Historique:
received:
10
10
2019
revised:
25
05
2020
accepted:
26
05
2020
pubmed:
2
6
2020
medline:
1
9
2020
entrez:
2
6
2020
Statut:
ppublish
Résumé
Triclocarban (TCC) is an antimicrobial compound, widely used in personal care products, such as soaps, toothpaste, and shampoo. This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Studies show that TCC has been associated with some endocrine disruptions. In vitro, TCC demonstrated potent androgen-augmenting activity and aromatase inhibition. In this sense, exposure during critical periods of development (gestation and lactation) could lead to some adverse health outcomes in offspring. Therefore, the present study evaluated if maternal exposure to three different doses of TCC could interfere in the reproductive parameters of male offspring. Pregnant female Wistar rats were separated into four groups: vehicle Control (CTR); TCC 0.3 mg/kg (TCC 0.3); TCC 1.5 mg/kg (TCC 1.5); TCC 3.0 mg/kg (TCC 3.0). Dams were treated daily by oral gavage from gestational day 0 to lactational day 21. The males were evaluated in different timepoint: infancy (PND 21), puberty (PND 50) and adult life (PND 90-120). The histomorphometric analysis of testis and testosterone level were assessed on PND 21, 50, 120; sexual behavior and sperm parameters at adulthood. In the TCC 3.0 group, a decrease in the testis interstitial volume and an increase in testosterone levels were observed on PND 21. Moreover, there was a decrease in the diameter of the seminiferous tubules on PND 50, and a decrease in sexual competency in adulthood. These results suggest that exposure to a human relevant dose of TCC may interfere with reproduction and could have implications for human health.
Identifiants
pubmed: 32479917
pii: S0041-008X(20)30201-5
doi: 10.1016/j.taap.2020.115077
pii:
doi:
Substances chimiques
Anti-Infective Agents, Local
0
Carbanilides
0
Testosterone
3XMK78S47O
triclocarban
BGG1Y1ED0Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115077Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.