Kidney Infarction in Patients With COVID-19.
Acute Kidney Injury
/ diagnostic imaging
Betacoronavirus
COVID-19
Coronavirus Infections
/ complications
Diagnosis, Differential
Heparin, Low-Molecular-Weight
/ pharmacology
Humans
Infarction
/ diagnostic imaging
Kidney
/ blood supply
Male
Middle Aged
Pandemics
Pneumonia, Viral
/ complications
SARS-CoV-2
Coronavirus disease 2019 (COVID-19)
acute kidney injury (AKI)
anticoagulation
arterial thrombi
case report
computed tomography (CT)
kidney infarction
renal complications of COVID-19
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
thrombotic events
Journal
American journal of kidney diseases : the official journal of the National Kidney Foundation
ISSN: 1523-6838
Titre abrégé: Am J Kidney Dis
Pays: United States
ID NLM: 8110075
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
16
04
2020
accepted:
23
05
2020
pubmed:
2
6
2020
medline:
2
9
2020
entrez:
2
6
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) is a contagious life-threatening infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent findings indicate an increased risk for acute kidney injury during COVID-19 infection. The pathophysiologic mechanisms leading to acute kidney injury in COVID-19 infection are unclear but may include direct cytopathic effects of the virus on kidney tubular and endothelial cells, indirect damage caused by virus-induced cytokine release, and kidney hypoperfusion due to a restrictive fluid strategy. In this report of 2 cases, we propose an additional pathophysiologic mechanism. We describe 2 cases in which patients with COVID-19 infection developed a decrease in kidney function due to kidney infarction. These patients did not have atrial fibrillation. One of these patients was treated with therapeutic doses of low-molecular-weight heparin, after which no further deterioration in kidney function was observed. Our findings implicate that the differential diagnosis of acute kidney injury in COVID-19-infected patients should include kidney infarction, which may have important preventive and therapeutic implications.
Identifiants
pubmed: 32479921
pii: S0272-6386(20)30723-X
doi: 10.1053/j.ajkd.2020.05.004
pmc: PMC7258815
pii:
doi:
Substances chimiques
Heparin, Low-Molecular-Weight
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
431-435Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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