Toll-like receptor 2 (TLR2)-deficiency impairs male mouse recovery from a depression-like state.
Depression
Inflammation
Pam3CSK4
Toll-like receptor-2
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
29
02
2020
revised:
25
05
2020
accepted:
26
05
2020
pubmed:
2
6
2020
medline:
28
4
2021
entrez:
2
6
2020
Statut:
ppublish
Résumé
Major depression is a prevalent, debilitating disease, yet therapeutic interventions for depression are frequently inadequate. Many clinical and pre-clinical studies have demonstrated that depression is associated with aberrant activation of the inflammatory system, raising the possibility that reducing inflammation may provide antidepressant effects. Using the learned helplessness mouse model, we tested if susceptibility or recovery were affected by deficiency in either of two receptors that initiate inflammatory signaling, Toll-like receptor-4 (TLR4) and TLR2, using knockout male mice. TLR4
Identifiants
pubmed: 32479995
pii: S0889-1591(20)30258-0
doi: 10.1016/j.bbi.2020.05.068
pmc: PMC7572513
mid: NIHMS1601279
pii:
doi:
Substances chimiques
Tlr2 protein, mouse
0
Toll-Like Receptor 2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-58Subventions
Organisme : BLRD VA
ID : I01 BX003678
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH104656
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110415
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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