Pyriproxyfen induced impairment of reproductive endocrine homeostasis and gonadal histopathology in zebrafish (Danio rerio) by altered expression of hypothalamus-pituitary-gonadal (HPG) axis genes.
Endocrine disruption
Estradiol
Ovary
Testes
Testosterone
Vitellogenin
Journal
The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500
Informations de publication
Date de publication:
15 Sep 2020
15 Sep 2020
Historique:
received:
30
01
2020
revised:
13
05
2020
accepted:
15
05
2020
pubmed:
2
6
2020
medline:
11
7
2020
entrez:
2
6
2020
Statut:
ppublish
Résumé
Pyriproxyfen (PPF), a broad-spectrum insecticide known to cause reproductive and endocrine disruption in invertebrates, while the data is scarce in aquatic vertebrates. The goal of this study is to investigate the impact of PPF on reproductive endocrine system of male and female zebrafish along hypothalamus-pituitary-gonadal (HPG) axis. In brain, PPF caused significant alteration in the transcripts of erα, lhβ, and cyp19b genes in male and fshβ, lhβ, and cyp19b genes in female zebrafish. The downstream genes of steroidogenic pathway like, star, 3βhsd, 17βhsd, and cyp19a expression were significantly altered in gonad of both sexes. Subsequent changes in circulatory steroid hormone levels lead to imbalance in hormone homeostasis as revealed from estradiol/testosterone (E
Identifiants
pubmed: 32480152
pii: S0048-9697(20)33013-8
doi: 10.1016/j.scitotenv.2020.139496
pii:
doi:
Substances chimiques
Endocrine Disruptors
0
Pyridines
0
Vitellogenins
0
Water Pollutants, Chemical
0
pyriproxyfen
3Q9VOR705O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
139496Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.