Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell-Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis.
Adult
Aging
/ blood
Blood Coagulation
/ physiology
Blood Platelets
/ physiology
Blood Proteins
/ physiology
Child
Child, Preschool
Endothelial Cells
/ physiology
Female
Fibrinolysis
/ physiology
Hemostasis
/ physiology
Humans
Infant
Infant, Newborn
Male
Middle Aged
Principal Component Analysis
Proteomics
Young Adult
hemostasis
pediatrics
plasma
platelet
proteomics
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
08
11
2019
revised:
09
01
2020
accepted:
22
01
2020
entrez:
3
6
2020
pubmed:
3
6
2020
medline:
28
10
2020
Statut:
ppublish
Résumé
This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children.
Identifiants
pubmed: 32482231
pii: S0022-3476(20)30123-2
doi: 10.1016/j.jpeds.2020.01.051
pii:
doi:
Substances chimiques
Blood Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
S29-S36Informations de copyright
Copyright © 2020. Published by Elsevier Inc.