Systemic lupus erythematosus, endothelial progenitor cells and intracellular Ca
Animals
Calcium
/ metabolism
Calcium Signaling
/ immunology
Cell Movement
/ immunology
Cell Proliferation
Disease Models, Animal
Endothelial Progenitor Cells
/ immunology
Humans
Lupus Erythematosus, Systemic
/ immunology
Myeloid Cells
/ immunology
Neovascularization, Pathologic
/ immunology
Paracrine Communication
/ immunology
Signal Transduction
/ immunology
Endothelial progenitor cells
Intracellular Ca(2+) signaling
Systemic lupus erythematosus
Journal
Journal of autoimmunity
ISSN: 1095-9157
Titre abrégé: J Autoimmun
Pays: England
ID NLM: 8812164
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
19
02
2020
revised:
07
05
2020
accepted:
09
05
2020
pubmed:
3
6
2020
medline:
13
10
2021
entrez:
3
6
2020
Statut:
ppublish
Résumé
Systemic lupus erythematosus (SLE) is an autoimmune multisystem disease featured by an increased cardiovascular risk that may lead to premature patient's death. It has been demonstrated that SLE patients suffer from early onset endothelial dysfunction which is due to the impairment of endogenous vascular repair mechanisms. Vascular integrity and homeostasis are maintained by endothelial progenitor cells (EPCs), which are mobilized in response to endothelial injury to replace damaged endothelial cells. Two main EPCs subpopulations exist in peripheral blood: endothelial colony forming cells (ECFCs), which represent truly endothelial precursors and can physically engraft within neovessels, and myeloid angiogenic cells (MACs), which sustain angiogenesis in a paracrine manner. Emerging evidence indicates that ECFCs/MACs are down-regulated and display compromised angiogenic activity in SLE, thereby contributing to the pathogenesis of this disease. Intracellular calcium (Ca
Identifiants
pubmed: 32482487
pii: S0896-8411(20)30104-9
doi: 10.1016/j.jaut.2020.102486
pii:
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102486Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.