GERD
Gastroesophageal reflux disease
Infant
Lactobacillus rhamnosus
Journal
Pediatric gastroenterology, hepatology & nutrition
ISSN: 2234-8646
Titre abrégé: Pediatr Gastroenterol Hepatol Nutr
Pays: Korea (South)
ID NLM: 101590471
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
03
10
2019
revised:
17
12
2019
accepted:
11
02
2020
entrez:
3
6
2020
pubmed:
3
6
2020
medline:
3
6
2020
Statut:
ppublish
Résumé
Proton-pump inhibitors (PPIs) are frequently used to treat gastroesophageal reflux disease (GERD) in children, but recent evidence suggests a potential association between PPI treatment and some types of infections. The aim of this study was to assess the effectiveness of Children younger than 5 years with GERD were assigned by a computer-generated list to receive LGG (10 Of 61 randomized children, 59 patients (LGG n=30; placebo n=29, mean age 11.3 months) were analyzed. There was no significant difference found between the LGG and placebo groups, either for the proportion of children with at least one respiratory tract infection (22/30 vs. 25/29, respectively; relative risk [RR] 0.85, 95% confidence interval [CI] 0.66-1.10) or for the proportion of children with at least one gastrointestinal infection (9/30 vs. 9/29, respectively; RR 0.97, 95% CI 0.45-2.09). LGG was not effective in the prevention of infectious complications in children with GERD receiving PPI. Caution is needed in interpreting these results, as the study was terminated early due to slow subject recruitment.
Identifiants
pubmed: 32483546
doi: 10.5223/pghn.2020.23.3.251
pmc: PMC7231745
doi:
Types de publication
Journal Article
Langues
eng
Pagination
251-258Informations de copyright
Copyright © 2020 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition.
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors have no financial conflicts of interest.
Références
J Neurogastroenterol Motil. 2018 Jan 30;24(1):51-57
pubmed: 29291607
Pediatrics. 2006 May;117(5):e817-20
pubmed: 16651285
J Pediatr Gastroenterol Nutr. 2010 Jun;50(6):609-18
pubmed: 20400912
J Pediatr. 2009 Apr;154(4):514-520.e4
pubmed: 19054529
Aliment Pharmacol Ther. 2016 May;43(10):1025-34
pubmed: 26991503
J Gastroenterol Hepatol. 2018 May;33(5):1059-1066
pubmed: 29105152
Eur J Pediatr. 2018 Jul;177(7):979-994
pubmed: 29752587
JAMA Pediatr. 2014 Oct;168(10):932-7
pubmed: 25133779
Eur J Gastroenterol Hepatol. 2011 Mar;23(3):232-7
pubmed: 21258240
Gastroenterology. 2019 Sep;157(3):682-691.e2
pubmed: 31152740
United European Gastroenterol J. 2017 Apr;5(3):335-358
pubmed: 28507746
Ther Adv Drug Saf. 2018 Nov 19;10:2042098618809927
pubmed: 31019676
JAMA. 2012 Jan 25;307(4):373-81
pubmed: 22274684
Gut. 2016 May;65(5):740-8
pubmed: 26657899
J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):516-554
pubmed: 29470322
Arch Dis Child. 2018 Jan;103(1):78-82
pubmed: 29237614
J Pediatr Gastroenterol Nutr. 2014 Apr;58(4):531-9
pubmed: 24614141
World J Gastroenterol. 2019 Jun 14;25(22):2706-2719
pubmed: 31235994
Adv Appl Microbiol. 2017;98:1-29
pubmed: 28189153
J Pediatr Gastroenterol Nutr. 2007 Oct;45(4):421-7
pubmed: 18030207
J Pediatr Gastroenterol Nutr. 2016 Mar;62(3):495-506
pubmed: 26756877
Gastroenterology. 2016 Feb 15;:
pubmed: 27144632
J Pediatr Gastroenterol Nutr. 2018 Jan;66(1):3-9
pubmed: 28574970
Endoscopy. 2015 Oct;47(10):a1-46
pubmed: 26417980
Clin Infect Dis. 2014 Apr;58(8):1107-15
pubmed: 24501384
Cochrane Database Syst Rev. 2019 Jun 18;6:CD012941
pubmed: 31210358
Arch Dis Child. 2018 Jul;103(7):660-664
pubmed: 29472195
J Pediatr Gastroenterol Nutr. 2017 Jun;64(6):991-1003
pubmed: 28541262