Topical Melatonin Niosome Gel for the Treatment of 5-FU-Induced Oral Mucositis in Mice.
5-fluorouracil
Malondialdehyde (MDA)
Niosomes
anti-inflammation
antioxidant
melatonin
mucositis
Journal
Current drug delivery
ISSN: 1875-5704
Titre abrégé: Curr Drug Deliv
Pays: United Arab Emirates
ID NLM: 101208455
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
09
2019
revised:
09
12
2019
accepted:
07
04
2020
pubmed:
3
6
2020
medline:
25
2
2023
entrez:
3
6
2020
Statut:
ppublish
Résumé
Oral mucositis, one of the most common complications of 5-Fluorouracil (5-FU) treatment, leads to several problems, including pain, diarrhea and malnutrition, and reduces the quality of life and subsequent treatments. Melatonin, a neurohormone with anti-inflammatory and antioxidant activities, was encapsulated in niosomes and embedded in a mucoadhesive gel formulation as a Melatonin Niosome Gel (MNG) to perform oral mucositis treatment. This study aimed to investigate the effectiveness of MNG for the treatment of 5-FU-induced oral mucositis in mice. Oral mucositis was induced in ICR mice by 5-FU and randomly assigned to receive daily applications of the topical oral MNG, a fluocinolone acetonide gel, a blank niosome gel, or no treatment for 5 days in comparison with a normal group. Average body weights, food consumption, and behaviors of the mice as well as microscopic histopathology, Fourier-Transform Infrared Spectroscopy (FTIR) analysis, proinflammatory cytokine levels, and oxidative stress markers of the tongues were monitored and collected after sacrifice. In comparison to the normal group, the average body weights of the 5-FU-MNG mice did not deviate from that of the normal group, nor was there a significant difference in the time to sleep or licking ( Topical MNG potentially inhibits inflammation and lipid oxidative stress in 5-FU-induced oral mucositis.
Sections du résumé
BACKGROUND
BACKGROUND
Oral mucositis, one of the most common complications of 5-Fluorouracil (5-FU) treatment, leads to several problems, including pain, diarrhea and malnutrition, and reduces the quality of life and subsequent treatments. Melatonin, a neurohormone with anti-inflammatory and antioxidant activities, was encapsulated in niosomes and embedded in a mucoadhesive gel formulation as a Melatonin Niosome Gel (MNG) to perform oral mucositis treatment.
OBJECTIVE
OBJECTIVE
This study aimed to investigate the effectiveness of MNG for the treatment of 5-FU-induced oral mucositis in mice.
METHODS
METHODS
Oral mucositis was induced in ICR mice by 5-FU and randomly assigned to receive daily applications of the topical oral MNG, a fluocinolone acetonide gel, a blank niosome gel, or no treatment for 5 days in comparison with a normal group. Average body weights, food consumption, and behaviors of the mice as well as microscopic histopathology, Fourier-Transform Infrared Spectroscopy (FTIR) analysis, proinflammatory cytokine levels, and oxidative stress markers of the tongues were monitored and collected after sacrifice.
RESULTS
RESULTS
In comparison to the normal group, the average body weights of the 5-FU-MNG mice did not deviate from that of the normal group, nor was there a significant difference in the time to sleep or licking (
CONCLUSION
CONCLUSIONS
Topical MNG potentially inhibits inflammation and lipid oxidative stress in 5-FU-induced oral mucositis.
Identifiants
pubmed: 32484102
pii: CDD-EPUB-106903
doi: 10.2174/1567201817666200525151848
doi:
Substances chimiques
Fluorouracil
U3P01618RT
Liposomes
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
199-211Informations de copyright
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