Culture conditions antagonize lineage-promoting signaling in the mouse blastocyst.
Journal
Reproduction (Cambridge, England)
ISSN: 1741-7899
Titre abrégé: Reproduction
Pays: England
ID NLM: 100966036
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
25
02
2020
accepted:
30
04
2020
entrez:
3
6
2020
pubmed:
3
6
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
The mouse preimplantation embryo is a paradigm for discovery of the molecular principles governing formation of specific cell types during development. In this Point of View Article, we show that conditions commonly used for ex vivo culture of preimplantation development are themselves antagonistic to a pathway that is critical for blastocyst lineage commitment.
Identifiants
pubmed: 32484160
doi: 10.1530/REP-20-0107
pii: REP-20-0107
pmc: PMC7301777
mid: NIHMS1592890
doi:
pii:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
V5-V7Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM131759
Pays : United States
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