Silencing of spontaneous activity at α4β1/3δ GABA


Journal

British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536

Informations de publication

Date de publication:
09 2020
Historique:
received: 27 05 2019
revised: 10 05 2020
accepted: 14 05 2020
pubmed: 3 6 2020
medline: 22 6 2021
entrez: 3 6 2020
Statut: ppublish

Résumé

The δ-subunit-containing GABA Whole-cell electrophysiological recordings of adult male rat and mouse hippocampal DGGCs were used to characterize known agonists and antagonists at δ-subunit-containing GABA Recordings at either 24°C or 34°C, including the PKC autoinhibitory peptide (19-36) intracellularly, removed spontaneous gating by GABA Kinase activity infers spontaneous gating in α

Sections du résumé

BACKGROUND AND PURPOSE
The δ-subunit-containing GABA
EXPERIMENTAL APPROACH
Whole-cell electrophysiological recordings of adult male rat and mouse hippocampal DGGCs were used to characterize known agonists and antagonists at δ-subunit-containing GABA
KEY RESULTS
Recordings at either 24°C or 34°C, including the PKC autoinhibitory peptide (19-36) intracellularly, removed spontaneous gating by GABA
CONCLUSION AND IMPLICATIONS
Kinase activity infers spontaneous gating in α

Identifiants

pubmed: 32484592
doi: 10.1111/bph.15146
pmc: PMC7429488
doi:

Substances chimiques

Ligands 0
Receptors, GABA-A 0
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3975-3990

Subventions

Organisme : Lundbeck Foundation
ID : R133-A12270
Organisme : Lundbeck Foundation
ID : R192-2015-666
Organisme : Lundbeck Foundation
ID : R230-2016-2562

Informations de copyright

© 2020 The British Pharmacological Society.

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Auteurs

Nils Ole Dalby (NO)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Christina Birkedahl Falk-Petersen (CB)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Ulrike Leurs (U)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Petra Scholze (P)

Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Jacob Krall (J)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Bente Frølund (B)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Petrine Wellendorph (P)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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Classifications MeSH