Adipose tissue macrophage burden, systemic inflammation, and insulin resistance.
Abdominal Fat
/ chemistry
Adipocytes
/ pathology
Adipose Tissue
/ pathology
Adult
Antigens, CD
/ analysis
Antigens, Differentiation, Myelomonocytic
/ analysis
Body Composition
Body Mass Index
Female
Humans
Inflammation
/ pathology
Insulin Resistance
/ physiology
Lectins, C-Type
/ analysis
Lipopolysaccharide Receptors
/ analysis
Macrophages
/ pathology
Male
Mannose Receptor
Mannose-Binding Lectins
/ analysis
Middle Aged
Obesity
/ pathology
Receptors, Cell Surface
/ analysis
Subcutaneous Fat
/ chemistry
IL-6
TNF
adipose tissue macrophage
body composition
immunohistochemistry
sex differences
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
pubmed:
3
6
2020
medline:
27
10
2020
entrez:
3
6
2020
Statut:
ppublish
Résumé
Adipose tissue inflammation, as defined by macrophage accumulation, is proposed to cause insulin resistance and systemic inflammation. Because the strength of this relationship for humans is unclear, we tested whether adipose tissue macrophage (ATM) burden is correlated with these health indicators. Using immunohistochemistry, we measured abdominal subcutaneous CD68+ (total ATM), CD14+ (proinflammatory/M1), and CD206+ (anti-inflammatory/M2) ATM in 97 volunteers (BMI 20-38 kg/m
Identifiants
pubmed: 32484712
doi: 10.1152/ajpendo.00109.2020
pmc: PMC7473914
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
CD14 protein, human
0
CD68 antigen, human
0
Lectins, C-Type
0
Lipopolysaccharide Receptors
0
Mannose Receptor
0
Mannose-Binding Lectins
0
Receptors, Cell Surface
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
E254-E264Subventions
Organisme : NIH/NIDDK
ID : DK40484
Pays : International
Organisme : NIH/NCRR
ID : 1UL1RR024150
Pays : International
Organisme : NIDDK NIH HHS
ID : R01 DK040484
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024150
Pays : United States
Organisme : NIH/NIDDK
ID : DK45343
Pays : International
Organisme : NIDDK NIH HHS
ID : T32 DK007352
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK045343
Pays : United States
Organisme : NIH/NIDDK
ID : 5T32 DK007352
Pays : International
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