Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study.
Adult
Air Pollutants
Air Pollution
/ statistics & numerical data
Aircraft
Cohort Studies
DNA
DNA Methylation
/ physiology
Environmental Exposure
/ statistics & numerical data
Female
Humans
Linear Models
Male
Middle Aged
Nitrogen Dioxide
Noise, Transportation
/ statistics & numerical data
Particulate Matter
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
entrez:
3
6
2020
pubmed:
3
6
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
Few epigenome-wide association studies (EWAS) on air pollutants exist, and none have been done on transportation noise exposures, which also contribute to environmental burden of disease. We performed mutually independent EWAS on transportation noise and air pollution exposures. We used data from two time points of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) from 1,389 participants contributing 2,542 observations. We applied multiexposure linear mixed-effects regressions with participant-level random intercept to identify significant Cytosine-phosphate-Guanine (CpG) sites and differentially methylated regions (DMRs) in relation to 1-y average aircraft, railway, and road traffic day-evening-night noise (Lden); nitrogen dioxide ( We found no statistically significant CpGs at false discovery rate Mutually independent DNA methylation was associated with source-specific transportation noise and air pollution exposures, with distinct and shared enrichments for pathways related to inflammation, cellular development, and immune responses. These findings contribute in clarifying the pathways linking these exposures and age-related diseases but need further confirmation in the context of mediation analyses. https://doi.org/10.1289/EHP6174.
Sections du résumé
BACKGROUND
Few epigenome-wide association studies (EWAS) on air pollutants exist, and none have been done on transportation noise exposures, which also contribute to environmental burden of disease.
OBJECTIVE
We performed mutually independent EWAS on transportation noise and air pollution exposures.
METHODS
We used data from two time points of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) from 1,389 participants contributing 2,542 observations. We applied multiexposure linear mixed-effects regressions with participant-level random intercept to identify significant Cytosine-phosphate-Guanine (CpG) sites and differentially methylated regions (DMRs) in relation to 1-y average aircraft, railway, and road traffic day-evening-night noise (Lden); nitrogen dioxide (
RESULTS
We found no statistically significant CpGs at false discovery rate
CONCLUSIONS
Mutually independent DNA methylation was associated with source-specific transportation noise and air pollution exposures, with distinct and shared enrichments for pathways related to inflammation, cellular development, and immune responses. These findings contribute in clarifying the pathways linking these exposures and age-related diseases but need further confirmation in the context of mediation analyses. https://doi.org/10.1289/EHP6174.
Identifiants
pubmed: 32484729
doi: 10.1289/EHP6174
pmc: PMC7263738
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
DNA
9007-49-2
Nitrogen Dioxide
S7G510RUBH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
67003Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT 084703MA
Pays : United Kingdom
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