Prenatal exposure to methadone or buprenorphine alters µ-opioid receptor binding and downstream signaling in the rat brain.
buprenorphine
methadone
neurobiological development
opioid maintenance treatment
prenatal exposure
µ-opioid receptor
Journal
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
ISSN: 1873-474X
Titre abrégé: Int J Dev Neurosci
Pays: United States
ID NLM: 8401784
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
revised:
14
05
2020
received:
27
03
2020
accepted:
27
05
2020
medline:
3
6
2020
pubmed:
3
6
2020
entrez:
3
6
2020
Statut:
ppublish
Résumé
There is a growing concern related to the use of opioid maintenance treatment during pregnancy. Studies in both humans and animals have reported reduced cognitive functioning in offspring prenatally exposed to methadone or buprenorphine; however, little is known about the neurobiological mechanisms underlying these impairments. To reveal possible neurobiological effects of such in utero exposure, we examined brain tissue from methadone- and buprenorphine-exposed rat offspring previously shown to display impaired learning and memory. We studied µ-opioid receptor (MOR) and N-methyl-D-aspartate receptor (NMDAR) binding in the rat offspring cerebrum during development and in the hippocampus at young adulthood. Moreover, we examined activation of the Ca
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
443-453Informations de copyright
© 2020 The Authors. International Journal of Developmental Neuroscience published by John Wiley & Sons Ltd on behalf of International Society for Developmental Neuroscience.
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