(Iso)Quinoline-Artemisinin Hybrids Prepared through Click Chemistry: Highly Potent Agents against Viruses.
antiviral agents
artemisinins
click chemistry
cycloaddition
quinolines
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
16 Sep 2020
16 Sep 2020
Historique:
received:
14
04
2020
pubmed:
3
6
2020
medline:
25
2
2021
entrez:
3
6
2020
Statut:
ppublish
Résumé
Viral infections cause life-threatening diseases in millions of people worldwide every year and there is an urgent need for new, effective antiviral drugs. Hybridization of two chemically diverse compounds into a new bioactive effector product is a successful concept to improve the properties of a hybrid drug relative to the parent compounds. In this study, (iso)quinoline-artemisinin hybrids, obtained through copper-catalyzed azide-alkyne cycloaddition or metal-free click reactions (in organic solvents or in the presence of water), were analyzed in vitro, for the first time, for their inhibitory activity against human cytomegalovirus (HCMV), relative to their parent compounds and the reference drug ganciclovir. EC
Identifiants
pubmed: 32485071
doi: 10.1002/chem.202001803
pmc: PMC7540715
doi:
Substances chimiques
Antiviral Agents
0
Artemisinins
0
Quinolines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12019-12026Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : TS 87/16-3
Organisme : Deutsche Forschungsgemeinschaft
ID : MM 1289/7-1/7-3
Organisme : Deutsche Forschungsgemeinschaft
ID : MM 1289/11-1
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 2504 (A1/MM)
Organisme : Deutsche Forschungsgemeinschaft
ID : Gottfried Wilhelm Leibniz award
Organisme : Deutscher Akademischer Austauschdienst
Organisme : Alexander von Humboldt-Stiftung
Organisme : ERDF/ESF
ID : ChemBioDrug CZ.02.1.01/0.0/0.0/16_019/0000729
Informations de copyright
© 2020 The Authors. Published by Wiley-VCH GmbH.
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