Defined p16
aging
fibrosis
lineage tracing
liver sinusoid endothelial cells
liver sinusoids
p16
senescence
vascular endothelial cells
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
07 07 2020
07 07 2020
Historique:
received:
29
08
2019
revised:
13
02
2020
accepted:
04
05
2020
pubmed:
3
6
2020
medline:
10
11
2021
entrez:
3
6
2020
Statut:
ppublish
Résumé
The accumulation of senescent cells can drive many age-associated phenotypes and pathologies. Consequently, it has been proposed that removing senescent cells might extend lifespan. Here, we generated two knockin mouse models targeting the best-characterized marker of senescence, p16
Identifiants
pubmed: 32485135
pii: S1550-4131(20)30241-2
doi: 10.1016/j.cmet.2020.05.002
pii:
doi:
Substances chimiques
Cdkn2a protein, mouse
0
Cyclin-Dependent Kinase Inhibitor p16
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
87-99.e6Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.