Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells.
actomyosin
caveolae
epithelial tension
extrusion
phosphoinositides
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
06 07 2020
06 07 2020
Historique:
received:
23
08
2019
revised:
17
03
2020
accepted:
01
05
2020
pubmed:
3
6
2020
medline:
2
1
2021
entrez:
3
6
2020
Statut:
ppublish
Résumé
Epithelia are active materials where mechanical tension governs morphogenesis and homeostasis. But how that tension is regulated remains incompletely understood. We now report that caveolae control epithelial tension and show that this is necessary for oncogene-transfected cells to be eliminated by apical extrusion. Depletion of caveolin-1 (CAV1) increased steady-state tensile stresses in epithelial monolayers. As a result, loss of CAV1 in the epithelial cells surrounding oncogene-expressing cells prevented their apical extrusion. Epithelial tension in CAV1-depleted monolayers was increased by cortical contractility at adherens junctions. This reflected a signaling pathway, where elevated levels of phosphoinositide-4,5-bisphosphate (PtdIns(4,5)P
Identifiants
pubmed: 32485139
pii: S1534-5807(20)30358-0
doi: 10.1016/j.devcel.2020.05.002
pii:
doi:
Substances chimiques
Cav1 protein, mouse
0
Caveolin 1
0
FMNL2 protein, mouse
0
Formins
0
Oncogene Proteins
0
Phosphatidylinositol 4,5-Diphosphate
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-91.e7Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.