p38 mitogen-activated protein kinase and pain.

Animals Clinical Trials as Topic Enzyme Activation Humans Pain / enzymology p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
Glial cells Pain p38 MAP kinase

Journal

Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521

Informations de publication

Date de publication:
01 Sep 2020
Historique:
received: 27 02 2020
revised: 23 05 2020
accepted: 28 05 2020
pubmed: 3 6 2020
medline: 1 9 2020
entrez: 3 6 2020
Statut: ppublish

Résumé

Inflammatory and neuropathic pain is initiated by tissue inflammation and nerve injury, respectively. Both are characterized by increased activity in the peripheral and central nervous system, where multiple inflammatory cytokines and other active molecules activate different signaling pathways that involve in the development and/or maintenance of pain. P38 mitogen-activated protein kinase (MAPK) is one member of the MAPK family, which is activated in neurons and glia and contributes importantly to inflammatory and neuropathic pain. The aim of this review is to summarize the latest advances made about the implication of p38 MAPK signaling cascade in pain. It can deepen our understanding of the molecular mechanisms of pain and may help to offer new targets for pain treatment.

Identifiants

DOI: 10.1016/j.lfs.2020.117885 PMID: 32485175
pubmed: 32485175
pii: S0024-3205(20)30635-4
doi: 10.1016/j.lfs.2020.117885
pii:
doi:

Substances chimiques

p38 Mitogen-Activated Protein Kinases EC 2.7.11.24

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

117885

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Lijia Mai (L)

Department of Anesthesiology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.

Xiao Zhu (X)

The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.

Fang Huang (F)

Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.

Hongwen He (H)

Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.

Wenguo Fan (W)

Department of Anesthesiology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China. Electronic address: fanweng@mail.sysu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › p38 mitogen-activated protein kinase and pain.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › p38 mitogen-activated protein kinase and pain.
questionsmedicales.fr › Métabolisme › Activation enzymatique › p38 mitogen-activated protein kinase and pain.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › p38 mitogen-activated protein kinase and pain.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › p38 mitogen-activated protein kinase and pain.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › p38 Mitogen-Activated Protein Kinases › p38 mitogen-activated protein kinase and pain.