Kinetics and metabolism of mercury in rats fed with mercury contaminated rice using mass balance and mercury isotope approach.
Mass balance
Mercury
Mercury isotope
Metabolism
Rat
Journal
The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500
Informations de publication
Date de publication:
20 Sep 2020
20 Sep 2020
Historique:
received:
06
03
2020
revised:
13
05
2020
accepted:
23
05
2020
pubmed:
3
6
2020
medline:
11
7
2020
entrez:
3
6
2020
Statut:
ppublish
Résumé
Consumption of mercury (Hg) contaminated rice can be a major environmental health issue but the toxicokinetics is not well known. Hg isotopes have been shown to be good tracers in studying Hg exposure and metabolic processes. We established a Hg mass balance and Hg isotope model in rats fed with Hg contaminated rice (THg 51.3 ng/g; MeHg 25 ng/g) for 90 days to investigate Hg toxicokinetics. Overall 80% of feeding THg was recovered in rat body and excrement, while the excrement accounted for 55% of total observed THg in rats. Feces were the main route of Hg elimination in rats, while urinary excretion was negligible. However, only 32% of utilized MeHg was recovered in rats, indicating significant demethylation of MeHg in rat body. Positive net fractionations of δ
Identifiants
pubmed: 32485364
pii: S0048-9697(20)33207-1
doi: 10.1016/j.scitotenv.2020.139687
pii:
doi:
Substances chimiques
Mercury Isotopes
0
Methylmercury Compounds
0
Mercury
FXS1BY2PGL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
139687Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.