Thermo-Responsive Antimicrobial Hydrogel for the In-Situ Coating of Mesh Materials for Hernia Repair.
Staphylococcus aureus
hernia
hyaluronic acid
infection prophylaxis
mesh coating
polypropylene
rifampicin
thermo-responsive hydrogel
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
29 May 2020
29 May 2020
Historique:
received:
11
05
2020
revised:
25
05
2020
accepted:
26
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
4
6
2020
Statut:
epublish
Résumé
The prophylactic coating of prosthetic mesh materials for hernia repair with antimicrobial compounds is commonly performed before implantation of the mesh in the abdominal wall. We propose a novel alternative, which is a rifampicin-loaded thermo-responsive hydrogel formulation, to be applied on the mesh after its implantation. This formulation becomes a gel in-situ once reached body temperature, allowing an optimal coating of the mesh along with the surrounding tissues. In vitro, the hydrogel cytotoxicity was assessed using rabbit fibroblasts and antimicrobial efficacy was determined against
Identifiants
pubmed: 32486080
pii: polym12061245
doi: 10.3390/polym12061245
pmc: PMC7362238
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Spanish Ministry of Science, Innovation and Universities
ID : SAF2017-89481-P
Organisme : European Hernia Society
ID : Research Grant 2019
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