RNA Sequencing-Based Identification of Ganglioside GD2-Positive Cancer Phenotype.
GD2-positive tumors
NGS
RNA sequencing
ganglioside GD2
ganglioside biosynthesis
glioma
immunotherapy
molecular diagnostics
neuroblastoma
targeted therapy
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
30 May 2020
30 May 2020
Historique:
received:
27
04
2020
revised:
20
05
2020
accepted:
27
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
4
6
2020
Statut:
epublish
Résumé
The tumor-associated ganglioside GD2 represents an attractive target for cancer immunotherapy. GD2-positive tumors are more responsive to such targeted therapy, and new methods are needed for the screening of GD2 molecular tumor phenotypes. In this work, we built a gene expression-based binary classifier predicting the GD2-positive tumor phenotypes. To this end, we compared RNA sequencing data from human tumor biopsy material from experimental samples and public databases as well as from GD2-positive and GD2-negative cancer cell lines, for expression levels of genes encoding enzymes involved in ganglioside biosynthesis. We identified a 2-gene expression signature combining ganglioside synthase genes
Identifiants
pubmed: 32486168
pii: biomedicines8060142
doi: 10.3390/biomedicines8060142
pmc: PMC7344710
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Russian Foundation for Basic Research
ID : 18-29-01029
Organisme : Russian Foundation for Basic Research
ID : 19-04-00758
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