Low Doses of Arsenic in a Mouse Model of Human Exposure and in Neuronal Culture Lead to S-Nitrosylation of Synaptic Proteins and Apoptosis via Nitric Oxide.
Acetyl Coenzyme A
/ metabolism
Animals
Apoptosis
Arsenic
/ analysis
Arsenites
Brain
/ metabolism
Calcium
/ metabolism
Computational Biology
Disease Models, Animal
Drinking Water
Humans
Mice
Mice, Inbred C57BL
Neurons
/ drug effects
Nitric Oxide
/ metabolism
Nitrogen
/ chemistry
Nitrosative Stress
Proteomics
Sodium Compounds
Water Pollutants
/ analysis
S-nitrosylation
acetyl-CoA
apoptosis
arsenic
brain cortex
brain disorders
mouse
nitric oxide
nitrosative stress
synaptic processes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 May 2020
31 May 2020
Historique:
received:
12
05
2020
revised:
26
05
2020
accepted:
27
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
2
4
2021
Statut:
epublish
Résumé
Accumulating public health and epidemiological literature support the hypothesis that arsenic in drinking water or food affects the brain adversely. Experiments on the consequences of nitric oxide (NO) formation in neuronal cell culture and mouse brain were conducted to probe the mechanistic pathways of nitrosative damage following arsenic exposure. After exposure of mouse embryonic neuronal cells to low doses of sodium arsenite (SA), we found that Ca This work develops a mechanistic understanding of the role of NO in arsenic-mediated toxicity in the brain, incorporating Ca
Sections du résumé
BACKGROUND
BACKGROUND
Accumulating public health and epidemiological literature support the hypothesis that arsenic in drinking water or food affects the brain adversely.
METHODS
METHODS
Experiments on the consequences of nitric oxide (NO) formation in neuronal cell culture and mouse brain were conducted to probe the mechanistic pathways of nitrosative damage following arsenic exposure.
RESULTS
RESULTS
After exposure of mouse embryonic neuronal cells to low doses of sodium arsenite (SA), we found that Ca
CONCLUSIONS
CONCLUSIONS
This work develops a mechanistic understanding of the role of NO in arsenic-mediated toxicity in the brain, incorporating Ca
Identifiants
pubmed: 32486366
pii: ijms21113948
doi: 10.3390/ijms21113948
pmc: PMC7312481
pii:
doi:
Substances chimiques
Arsenites
0
Drinking Water
0
Sodium Compounds
0
Water Pollutants
0
Nitric Oxide
31C4KY9ESH
sodium arsenite
48OVY2OC72
Acetyl Coenzyme A
72-89-9
Arsenic
N712M78A8G
Nitrogen
N762921K75
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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