NF-κB and Its Role in Checkpoint Control.
Animals
B7-H1 Antigen
/ metabolism
Cell Line, Tumor
Cyclin-Dependent Kinase 4
/ antagonists & inhibitors
Cyclooxygenase 2
/ metabolism
Cyclooxygenase Inhibitors
/ pharmacology
Cytokines
/ metabolism
ErbB Receptors
/ metabolism
Gene Expression Regulation, Neoplastic
Humans
Immune Checkpoint Inhibitors
/ pharmacology
Inflammation
/ metabolism
Mice
NF-kappa B
/ metabolism
Neoplasms
/ metabolism
Pentoxifylline
/ pharmacology
Protein Kinase Inhibitors
/ pharmacology
Protein Processing, Post-Translational
Signal Transduction
Toll-Like Receptors
/ metabolism
Tumor Necrosis Factor-alpha
/ antagonists & inhibitors
NF-κB
PD-L1
immune checkpoint expression
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 May 2020
31 May 2020
Historique:
received:
06
05
2020
revised:
25
05
2020
accepted:
28
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
2
4
2021
Statut:
epublish
Résumé
Nuclear factor-κB (NF-κB) has been described as one of the most important molecules linking inflammation to cancer. More recently, it has become clear that NF-κB is also involved in the regulation of immune checkpoint expression. Therapeutic approaches targeting immune checkpoint molecules, enabling the immune system to initiate immune responses against tumor cells, constitute a key breakthrough in cancer treatment. This review discusses recent evidence for an association of NF-κB and immune checkpoint expression and examines the therapeutic potential of inhibitors targeting either NF-κB directly or molecules involved in NF-κB regulation in combination with immune checkpoint blockade.
Identifiants
pubmed: 32486375
pii: ijms21113949
doi: 10.3390/ijms21113949
pmc: PMC7312739
pii:
doi:
Substances chimiques
B7-H1 Antigen
0
CD274 protein, human
0
Cyclooxygenase Inhibitors
0
Cytokines
0
Immune Checkpoint Inhibitors
0
NF-kappa B
0
Protein Kinase Inhibitors
0
Toll-Like Receptors
0
Tumor Necrosis Factor-alpha
0
Cyclooxygenase 2
EC 1.14.99.1
ErbB Receptors
EC 2.7.10.1
Cyclin-Dependent Kinase 4
EC 2.7.11.22
Pentoxifylline
SD6QCT3TSU
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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