Neurogenic pulmonary edema following febrile status epilepticus in a 22-month-old infant with multiple respiratory virus co-detection: a case report.
Central Nervous System Diseases
/ etiology
Coronavirus
/ isolation & purification
Coronavirus Infections
Female
Fever
/ complications
Humans
Infant
Influenza, Human
Gammainfluenzavirus
/ isolation & purification
Molecular Diagnostic Techniques
Nasopharynx
/ virology
Parainfluenza Virus 2, Human
/ isolation & purification
Pulmonary Edema
/ diagnostic imaging
Respiratory Tract Infections
/ complications
Status Epilepticus
Co-detection
Febrile status epilepticus
Human coronavirus HKU1
Human parainfluenza virus 2
Influenza C virus
Multiplex real-time RT-PCR
Neurogenic pulmonary edema
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
01 Jun 2020
01 Jun 2020
Historique:
received:
21
07
2019
accepted:
24
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
4
8
2020
Statut:
epublish
Résumé
Neurogenic pulmonary edema is a rare but serious complication of febrile status epilepticus in children. Comprehensive screening for viral pathogens is seldomly performed in the work-up of febrile children. A 22-month-old girl presented with her first episode of febrile status epilepticus, after which she developed acute pulmonary edema and respiratory failure. After the termination of seizure activity, the patient was intubated and managed on mechanical ventilation in the emergency room. The resolution of respiratory failure, as well as the neurological recovery, was achieved 9 h after admission, and the patient was discharged 6 days after admission without any complications. Molecular biological diagnostic methods identified the presence of human coronavirus HKU1, influenza C virus, and human parainfluenza virus 2 from the patient's nasopharyngeal specimens. Neurogenic pulmonary edema following febrile status epilepticus was suspected to be the etiology of our patient's acute pulmonary edema and respiratory failure. Timely seizure termination and rapid airway and respiratory intervention resulted in favorable outcomes of the patient. Molecular biological diagnostic methods identified three respiratory viruses; however, their relevance and association with clinical symptoms remain speculative.
Sections du résumé
BACKGROUND
BACKGROUND
Neurogenic pulmonary edema is a rare but serious complication of febrile status epilepticus in children. Comprehensive screening for viral pathogens is seldomly performed in the work-up of febrile children.
CASE PRESENTATION
METHODS
A 22-month-old girl presented with her first episode of febrile status epilepticus, after which she developed acute pulmonary edema and respiratory failure. After the termination of seizure activity, the patient was intubated and managed on mechanical ventilation in the emergency room. The resolution of respiratory failure, as well as the neurological recovery, was achieved 9 h after admission, and the patient was discharged 6 days after admission without any complications. Molecular biological diagnostic methods identified the presence of human coronavirus HKU1, influenza C virus, and human parainfluenza virus 2 from the patient's nasopharyngeal specimens.
CONCLUSIONS
CONCLUSIONS
Neurogenic pulmonary edema following febrile status epilepticus was suspected to be the etiology of our patient's acute pulmonary edema and respiratory failure. Timely seizure termination and rapid airway and respiratory intervention resulted in favorable outcomes of the patient. Molecular biological diagnostic methods identified three respiratory viruses; however, their relevance and association with clinical symptoms remain speculative.
Identifiants
pubmed: 32487032
doi: 10.1186/s12879-020-05115-2
pii: 10.1186/s12879-020-05115-2
pmc: PMC7266127
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
388Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP18fk0108019
Organisme : Japan Agency for Medical Research and Development
ID : JP18fk0108030
Organisme : Japan Agency for Medical Research and Development
ID : JP18fk0108030
Organisme : Japan Agency for Medical Research and Development
ID : JP18fk0108030
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