Unraveling the Epigenetic Basis of Liver Development, Regeneration and Disease.
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
23
01
2020
revised:
10
05
2020
accepted:
11
05
2020
pubmed:
4
6
2020
medline:
27
5
2021
entrez:
4
6
2020
Statut:
ppublish
Résumé
A wealth of studies over several decades has revealed an epigenetic prepattern that determines the competence of cellular differentiation in the developing liver. More recently, studies focused on the impact of epigenetic factors during liver regeneration suggest that an epigenetic code in the quiescent liver may establish its regenerative potential. We review work on the pioneer factors and other chromatin remodelers that impact the gene expression patterns instructing hepatocyte and biliary cell specification and differentiation, along with the requirement of epigenetic regulatory factors for hepatic outgrowth. We then explore recent studies involving the role of epigenetic regulators, Arid1a and Uhrf1, in efficient activation of proregenerative genes during liver regeneration, thus highlighting the epigenetic mechanisms of liver disease and tumor development.
Identifiants
pubmed: 32487496
pii: S0168-9525(20)30099-8
doi: 10.1016/j.tig.2020.05.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
587-597Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.