Oncological Safety of Ultrasonically Activated Surgical Devices During Gastric Cancer Surgery.
Ultrasonically-activated surgical device
dissemination
gastric cancer
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
11
04
2020
revised:
17
04
2020
accepted:
18
04
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
13
6
2020
Statut:
ppublish
Résumé
Ultrasonically activated surgical devices (USADs) have become indispensable instruments for gastrointestinal surgery. In this study, we investigated the oncological safety of the use of USADs. We harvested and cultivated the splashes and mist scattered from an USAD when cutting MKN45-derived cancer nodules. Seven days later, we observed viable cancer cells and the total number of cells was counted. The histopathology of the nodules cut by the USAD was also examined. The existence of viable cancer cells was confirmed by ex vivo cell culture. The number of viable cancer cells was reduced by slow grasping of the USAD. The surface of cancerous tissue cut by the USAD was partially heat-denatured, however, there were some parts in which cancerous tissue was exposed on the surface. Surgeons should recognize the possibility that cancer cells may be scattered by USAD use.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Ultrasonically activated surgical devices (USADs) have become indispensable instruments for gastrointestinal surgery. In this study, we investigated the oncological safety of the use of USADs.
MATERIALS AND METHODS
METHODS
We harvested and cultivated the splashes and mist scattered from an USAD when cutting MKN45-derived cancer nodules. Seven days later, we observed viable cancer cells and the total number of cells was counted. The histopathology of the nodules cut by the USAD was also examined.
RESULTS
RESULTS
The existence of viable cancer cells was confirmed by ex vivo cell culture. The number of viable cancer cells was reduced by slow grasping of the USAD. The surface of cancerous tissue cut by the USAD was partially heat-denatured, however, there were some parts in which cancerous tissue was exposed on the surface.
CONCLUSION
CONCLUSIONS
Surgeons should recognize the possibility that cancer cells may be scattered by USAD use.
Identifiants
pubmed: 32487611
pii: 40/6/3163
doi: 10.21873/anticanres.14298
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3163-3167Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.