Predicting Stereopsis in Macular Degeneration.
human
macular degeneration
stereopsis
upper disparity limit
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
08 07 2020
08 07 2020
Historique:
received:
29
02
2020
revised:
10
04
2020
accepted:
25
05
2020
pubmed:
4
6
2020
medline:
27
11
2020
entrez:
4
6
2020
Statut:
ppublish
Résumé
Each of our eyes sees a slightly different view of the physical world. Disparity is the small difference in position of features in the retinal images; stereopsis is the percept of depth from disparity. A distance between corresponding features in the retinal images of the two eyes smaller than the "upper disparity limit" yields a percept of depth; distances greater than this limit cause the two unfused monocular features to appear flattened into the fixation plane. This behavioral disparity limit is consistent with neurophysiological estimates of the largest disparity scale in primate, allowing us to relate physiological limits on plausible binocular interactions to separation between retinal locations. Here we test the hypothesis that this upper disparity limit predicts the presence of coarse stereopsis in humans with macular degeneration (MD), which affects the central retina but typically spares the periphery. The pattern of vision loss can be highly asymmetric, such that an intact location in one eye has a corresponding point in the other eye that lies within affected retina. Nevertheless, some individuals with MD have coarse stereopsis that is useful for eye-hand coordination. Our results show that individuals with MD (
Identifiants
pubmed: 32487694
pii: JNEUROSCI.0491-20.2020
doi: 10.1523/JNEUROSCI.0491-20.2020
pmc: PMC7343329
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5465-5470Subventions
Organisme : NEI NIH HHS
ID : R01 EY027390
Pays : United States
Informations de copyright
Copyright © 2020 the authors.
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