Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms.
Animals
Caenorhabditis elegans Proteins
Circadian Rhythm
/ physiology
Disease Models, Animal
Erythropoiesis
/ physiology
Female
Gene Expression
Host-Parasite Interactions
/ genetics
Humans
Malaria
/ metabolism
Mice
Mice, Knockout
Plasmodium chabaudi
/ genetics
Plasmodium falciparum
/ genetics
Protozoan Proteins
/ genetics
Receptors, G-Protein-Coupled
/ genetics
Rodentia
Secologanin Tryptamine Alkaloids
/ metabolism
Transcriptome
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 06 2020
02 06 2020
Historique:
received:
18
08
2019
accepted:
04
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
25
8
2020
Statut:
epublish
Résumé
Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown. Combining in vivo and in vitro approaches utilizing rodent and human malaria parasites, we reveal that: (i) 57% of Plasmodium chabaudi genes exhibit daily rhythms in transcription; (ii) 58% of these genes lose transcriptional rhythmicity when the IDC is out-of-synchrony with host rhythms; (iii) 6% of Plasmodium falciparum genes show 24 h rhythms in expression under free-running conditions; (iv) Serpentine receptor 10 (SR10) has a 24 h transcriptional rhythm and disrupting it in rodent malaria parasites shortens the IDC by 2-3 h; (v) Multiple processes including DNA replication, and the ubiquitin and proteasome pathways, are affected by loss of coordination with host rhythms and by disruption of SR10. Our results reveal malaria parasites are at least partly responsible for scheduling the IDC and coordinating their development with host daily rhythms.
Identifiants
pubmed: 32488076
doi: 10.1038/s41467-020-16593-y
pii: 10.1038/s41467-020-16593-y
pmc: PMC7265539
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Protozoan Proteins
0
Receptors, G-Protein-Coupled
0
SRD-1 protein, C elegans
0
Secologanin Tryptamine Alkaloids
0
serpentine (alkaloid)
B503RKE34F
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2763Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202769/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204511/Z/16/Z
Pays : United Kingdom
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