Multicentre analysis of hyperglycaemic hyperosmolar state and diabetic ketoacidosis in type 1 and type 2 diabetes.
Adolescent
Adult
Aged
Austria
/ epidemiology
Child
Diabetes Mellitus, Type 1
/ blood
Diabetes Mellitus, Type 2
/ blood
Diabetic Ketoacidosis
/ blood
Female
Follow-Up Studies
Germany
/ epidemiology
Humans
Hyperglycemia
/ blood
Hyperglycemic Hyperosmolar Nonketotic Coma
/ blood
Luxembourg
/ epidemiology
Male
Middle Aged
Registries
Switzerland
/ epidemiology
Young Adult
Acute complication
Diabetic ketoacidosis
Hyperglycaemic hyperosmolar state
Metabolic decompensation
Multicentre registry
Journal
Acta diabetologica
ISSN: 1432-5233
Titre abrégé: Acta Diabetol
Pays: Germany
ID NLM: 9200299
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
12
12
2019
accepted:
18
04
2020
pubmed:
4
6
2020
medline:
20
11
2020
entrez:
4
6
2020
Statut:
ppublish
Résumé
To compare diabetes patients with hyperglycaemic hyperosmolar state (HHS), diabetic ketoacidosis (DKA), and patients without decompensation (ND). In total, 500,973 patients with type 1 or type 2 diabetes of all ages registered in the diabetes patient follow-up (DPV) were included. Analysis was stratified by age (≤ / > 20 years) and by manifestation/follow-up. Patients were categorized into three groups: HHS or DKA-during follow-up according to the most recent episode-or ND. At onset of diabetes, HHS criteria were met by 345 (68.4% T1D) and DKA by 9824 (97.6% T1D) patients. DKA patients had a lower BMI(-SDS) in both diabetes types compared to ND. HbA1c was higher in HHS/DKA. During follow-up, HHS occurred in 1451 (42.2% T1D) and DKA in 8389 patients (76.7% T1D). In paediatric T1D, HHS/DKA was associated with younger age, depression, and dyslipidemia. Pump usage was less frequent in DKA patients. In adult T1D/T2D subjects, metabolic control was worse in patients with HHS/DKA. HHS and DKA were also associated with excessive alcohol intake, dementia, stroke, chronic kidney disease, and depression. HHS/DKA occurred mostly in T1D and younger patients. However, both also occurred in T2D, which is of great importance in the treatment of diabetes. Better education programmes are necessary to prevent decompensation and comorbidities.
Identifiants
pubmed: 32488499
doi: 10.1007/s00592-020-01538-0
pii: 10.1007/s00592-020-01538-0
pmc: PMC7496062
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1245-1253Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : FKZ 82DZD0017G
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