Effect of treadmill exercise on catalepsy and the expression of the BDNF gene in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine -induced Parkinson in male
BDNF
Catalepsy
Exercise
IL-10
Parkinson’s disease
Journal
Iranian journal of basic medical sciences
ISSN: 2008-3866
Titre abrégé: Iran J Basic Med Sci
Pays: Iran
ID NLM: 101517966
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
4
6
2020
Statut:
ppublish
Résumé
It is known that treadmill exercise has beneficial effects on the nervous system. The brain-derived neurotrophic factor (BDNF) plays a role in such effects. This study aimed at investigating effects of intermittent treadmill exercise-induced behavioral, histology, and immunohistochemistry (H&E, TH) measurement of brain interleukin-10 (IL-10) in a mice male model of Parkinson's disease (PD), which is induced by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), as well as the role of BDNF gene in exercise effects. The animals were divided into Control (C), Saline (S), Parkinson (P), Exercise (E), and Parkinson + Exercise (PE) groups. Bar test was performed for the 21-day protocol with 5 days a week treadmill exercises. In this regard, brains were removed from the skull for H&E, TH, IL-10, and the expression of the BDNF gene using the MPTP male mice PD model. MPTP reduced the number of DA neurons in the substantia nigra (SNpc), whereas daily exercise administration on 1 The treadmill exercise having neuroprotective effects in SNpc and corpus striatum has improved MPTP associated with motor deficits. It is considered as a non-pharmacological tool for the management of PD.
Identifiants
pubmed: 32489563
doi: 10.22038/ijbms.2020.37707.8960
pmc: PMC7239421
doi:
Types de publication
Journal Article
Langues
eng
Pagination
483-493Références
J Neurosci. 2005 Jun 29;25(26):6251-9
pubmed: 15987955
J Neural Transm (Vienna). 2010 Aug;117(8):971-9
pubmed: 20571837
J Neurotrauma. 2013 Jan 1;30(1):47-54
pubmed: 21851230
Exp Neurol. 2010 Nov;226(1):136-47
pubmed: 20713051
Mech Ageing Dev. 2011 Nov-Dec;132(11-12):560-7
pubmed: 21983475
Trends Immunol. 2002 Feb;23(2):89-96
pubmed: 11929132
Environ Health Perspect. 2009 Jan;117(1):117-21
pubmed: 19165397
Sports Med. 2010 Sep 1;40(9):765-801
pubmed: 20726622
J Neural Transm (Vienna). 2017 Aug;124(8):901-905
pubmed: 28150045
Eur J Neurosci. 2011 Apr;33(7):1264-74
pubmed: 21375602
J Neurosci. 2007 Mar 21;27(12):3328-37
pubmed: 17376993
Neuron. 2008 Dec 10;60(5):748-66
pubmed: 19081372
Neurosci Lett. 2008 Aug 22;441(2):158-62
pubmed: 18582534
Prog Neurobiol. 2001 Jan;63(1):71-124
pubmed: 11040419
Neurobiol Aging. 2006 Jun;27(6):862-70
pubmed: 15913845
J Neurochem. 2003 Apr;85(2):299-305
pubmed: 12675906
Parkinsonism Relat Disord. 2005 Dec;11(8):493-8
pubmed: 16154792
J Neurochem. 2012 Feb;120(4):541-51
pubmed: 22136399
Immunology. 2010 Feb;129(2):154-69
pubmed: 20561356
NeuroRx. 2005 Jul;2(3):484-94
pubmed: 16389312
Brain Behav Immun. 2011 Jan;25(1):135-46
pubmed: 20851176
J Neurochem. 1997 Sep;69(3):1322-5
pubmed: 9282960
Brain Res. 2010 Jan 15;1310:200-7
pubmed: 19900418
Neurosci Lett. 2004 Dec 6;372(3):256-61
pubmed: 15542251
Neurol India. 2017 Mar-Apr;65(2):263-268
pubmed: 28290386
Brain Res Brain Res Rev. 2000 Sep;33(2-3):199-227
pubmed: 11011066
Stroke. 2009 Apr;40(4):1490-5
pubmed: 19164786
J Parkinsons Dis. 2011;1(1):19-33
pubmed: 23275799
Mol Neurobiol. 2013 Apr;47(2):460-5
pubmed: 23180276
Front Neuroendocrinol. 2006 Dec;27(4):404-14
pubmed: 17069877
Neurosci Lett. 2012 Oct 31;529(1):28-32
pubmed: 22999926
Exp Neurol. 2015 Jan;263:50-62
pubmed: 25286336
NeuroRehabilitation. 2002;17(2):161-8
pubmed: 12082243
Neurobiol Dis. 2010 Mar;37(3):510-8
pubmed: 19913097
Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1:S123-7
pubmed: 24262162
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):65-75
pubmed: 16183338
Neurotox Res. 2016 Jan;29(1):118-25
pubmed: 26464310
Neurotox Res. 2013 Oct;24(3):393-406
pubmed: 23893731
Neuroscience. 2012 Jan 27;202:252-66
pubmed: 22183054
J Neurosci Res. 2004 Aug 1;77(3):378-90
pubmed: 15248294
Neuroscience. 2003;119(3):899-911
pubmed: 12809709
Lancet Neurol. 2013 Jul;12(7):716-26
pubmed: 23769598
J Parkinsons Dis. 2015;5(2):229-39
pubmed: 25649828
J Neurosci Res. 1995 Dec;42(5):724-32
pubmed: 8600306
PLoS One. 2015 Feb 18;10(2):e0117391
pubmed: 25693197
Life Sci. 2012 Dec 17;91(25-26):1309-16
pubmed: 23069581
Mol Neurobiol. 2015 Apr;51(2):487-99
pubmed: 24859383
Neurobiol Dis. 2007 Feb;25(2):378-91
pubmed: 17141511
J Pharmacol Exp Ther. 2006 Oct;319(1):44-52
pubmed: 16807359
Neurobiol Learn Mem. 2012 Jan;97(1):140-7
pubmed: 22085720
Brain Res Mol Brain Res. 2005 Mar 24;134(1):170-9
pubmed: 15790541
Neuromolecular Med. 2014 Mar;16(1):161-174
pubmed: 24114393
Lancet Neurol. 2011 Dec;10(12):1108-18
pubmed: 22094131
Eur J Neurosci. 2009 Mar;29(5):954-63
pubmed: 19245367
Brain Res Mol Brain Res. 2003 Jun 10;114(2):168-71
pubmed: 12829328
Exp Physiol. 2009 Oct;94(10):1062-9
pubmed: 19666694
Brain Res Mol Brain Res. 2005 Mar 24;134(1):57-66
pubmed: 15790530
Eur J Neurosci. 2011 Feb;33(3):383-90
pubmed: 21198979
Br J Pharmacol. 2014 Apr;171(8):2206-29
pubmed: 24720259
Neurochem Res. 2009 Jan;34(1):55-65
pubmed: 18363100
Brain Res. 2011 Mar 10;1378:105-18
pubmed: 21236244
Acta Neurol Scand. 2009 May;119(5):332-7
pubmed: 18976327
Sci Rep. 2013;3:1393
pubmed: 23462811
Neuroscience. 2012 Dec 27;227:305-12
pubmed: 23041759
Neuroimmunomodulation. 2011;18(2):79-88
pubmed: 20938211
Arch Phys Med Rehabil. 2012 Nov;93(11):2049-54
pubmed: 22659536
Glia. 2000 Apr;30(2):134-42
pubmed: 10719355
Neuroreport. 1999 Feb 25;10(3):557-61
pubmed: 10208589
BMC Neurosci. 2010 Apr 26;11:52
pubmed: 20420688
Psychopharmacology (Berl). 1995 Jul;120(2):128-33
pubmed: 7480543
Growth Factors. 2004 Sep;22(3):123-31
pubmed: 15518235
Immunopharmacol Immunotoxicol. 2008;30(4):729-40
pubmed: 18686098
Eur J Neurosci. 2007 Sep;26(6):1500-8
pubmed: 17714494
Neurobiol Dis. 2013 Nov;59:38-51
pubmed: 23867236
Exp Neurol. 2011 Mar;228(1):118-25
pubmed: 21192928
Exp Neurol. 2000 Nov;166(1):127-35
pubmed: 11031089
Behav Brain Res. 2001 Nov 1;125(1-2):109-25
pubmed: 11682102