COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?

ACE2 COVID-19 India cross-immunity mortality transmission

Journal

Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533

Informations de publication

Date de publication:
May 2020
Historique:
received: 26 03 2020
accepted: 02 04 2020
entrez: 4 6 2020
pubmed: 4 6 2020
medline: 4 6 2020
Statut: epublish

Résumé

The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. The Indian government has taken appropriate and commendable steps to curtail the community spread of COVID-19. While this may be extremely beneficial, this perspective discusses the other reasons why COVID-19 may have a lesser impact on India. We analyze the current pattern of SARS-CoV-2 transmission, testing, and mortality in India with an emphasis on the importance of mortality as a marker of the clinical relevance of COVID-19 disease. We also analyze the environmental and biological factors which may lessen the impact of COVID-19 in India. The importance of cross-immunity, innate immune responses, ACE polymorphism, and viral genetic mutations are discussed.

Identifiants

DOI: 10.14336/AD.2020.0402 PMID: 32489695 PMC: PMC7220291
pubmed: 32489695
doi: 10.14336/AD.2020.0402
pii: ad-11-3-480
pmc: PMC7220291
doi:

Types de publication

Journal Article

Langues

eng

Pagination

480-488

Informations de copyright

Copyright: © 2020 Chakrabarti et al.

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Auteurs

Sankha Shubhra Chakrabarti (SS)

1Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.

Upinder Kaur (U)

2Department of Pharmacology, All India Institute of Medical Sciences, Gorakhpur, UP, India.

Anindita Banerjee (A)

3Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Upasana Ganguly (U)

3Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Tuhina Banerjee (T)

4Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, UP, India.

Sarama Saha (S)

5Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Gaurav Parashar (G)

6Department of Biotechnology, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.

Suvarna Prasad (S)

7Department of Biochemistry, MM Institute of Medical Sciences & Research, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.

Suddhachitta Chakrabarti (S)

8Health Department, Kolkata Municipal Corporation, West Bengal, India.

Amit Mittal (A)

9Department of Radiodiagnosis, MM Institute of Medical Sciences & Research, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.

Bimal Kumar Agrawal (BK)

10Department of General Medicine, MM Institute of Medical Sciences & Research, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.

Ravindra Kumar Rawal (RK)

11Department of Chemistry, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.

Robert Chunhua Zhao (RC)

12School of Life Sciences, Shanghai University, Shanghai, China.

Indrajeet Singh Gambhir (IS)

13Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.

Rahul Khanna (R)

14Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.

Ashok K Shetty (AK)

15Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, Texas A&M University College of Medicine, College Station, Texas, USA.

Kunlin Jin (K)

16Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.

Sasanka Chakrabarti (S)

17Department of Biochemistry and Central Research Cell, MM Institute of Medical Sciences & Research, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.

Classifications MeSH