Associations between PTSD-Related extinction retention deficits in women and plasma steroids that modulate brain GABA
Allopregnanolone
Dehydroepiandrosterone
Extinction retention
Fear extinction
Neurosteroid
PTSD
Pregnanolone
Progesterone
Journal
Neurobiology of stress
ISSN: 2352-2895
Titre abrégé: Neurobiol Stress
Pays: United States
ID NLM: 101643409
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
28
10
2019
revised:
14
04
2020
accepted:
25
04
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
4
6
2020
Statut:
epublish
Résumé
Several studies have demonstrated poor retention of extinction learning among individuals with posttraumatic stress disorder (PTSD). Gonadal hormone signaling in brain appears to influence the retention of extinction learning differently in women with and without PTSD. Women with PTSD, compared to trauma-exposed women without PTSD, show relative deficits in extinction retention during the mid-luteal phase (mLP) of the menstrual cycle, compared to the early follicular phase (eFP). A PTSD-related reduction in conversion of progesterone to its GABAergic metabolites allopregnanolone (Allo) and pregnanolone (PA) may contribute to these findings. The current study in trauma-exposed women with (n = 9) and without (n = 9) PTSD investigated associations between extinction retention and plasma Allo + PA levels, as well as the ratio of Allo + PA to 5α-dihydroprogesterone (5α-DHP), the immediate steroid precursor for Allo. The study also investigated the relationship between extinction retention and the ratio of Allo + PA to dehydroepiandrosterone (DHEA), an adrenally-derived GABA
Identifiants
pubmed: 32490055
doi: 10.1016/j.ynstr.2020.100225
pii: S2352-2895(20)30015-1
pii: 100225
pmc: PMC7256058
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100225Subventions
Organisme : NICHD NIH HHS
ID : K23 HD087428
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH122867
Pays : United States
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