Social support modulates the association between PTSD diagnosis and medial frontal volume in Chinese adults who lost their only child.
Age
Post-traumatic stress disorder
Sex
Social support
Voxel-based morphometry
Journal
Neurobiology of stress
ISSN: 2352-2895
Titre abrégé: Neurobiol Stress
Pays: United States
ID NLM: 101643409
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
09
11
2019
revised:
03
04
2020
accepted:
02
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
4
6
2020
Statut:
epublish
Résumé
Losing an only child is a devastating life event that a parent can experience and may lead to post-traumatic stress disorder (PTSD). Social support could buffer against the negative influence of this trauma, but the neural mechanism underlying this alleviation effect remains poorly understood. In this study, voxel-based morphometry was conducted on brain MRI of 220 Han Chinese adults who had lost their only child. We performed multiple regression analysis to investigate the associations between social support scores - along with PTSD diagnosis, age, sex, body mass index (BMI) - and brain grey matter (GM) volumes in these bereaved parents. For all trauma-exposed adults, social support-by-diagnosis interaction was significantly associated with medial prefrontal volume (multiple comparisons corrected
Identifiants
pubmed: 32490056
doi: 10.1016/j.ynstr.2020.100227
pii: S2352-2895(20)30017-5
pii: 100227
pmc: PMC7256056
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100227Informations de copyright
© 2020 The Author(s).
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