Proteomic profiles of incident mild cognitive impairment and Alzheimer's disease among adults with Down syndrome.
Down syndrome
dementia
mild cognitive impairment
plasma
proteomic
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
12
2019
revised:
05
03
2020
accepted:
06
03
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
4
6
2020
Statut:
epublish
Résumé
We sought to determine if proteomic profiles could predict risk for incident mild cognitive impairment (MCI) and Alzheimer's disease (AD) among adults with Down syndrome (DS). In a cohort of 398 adults with DS, a total of n = 186 participants were determined to be non-demented and without MCI or AD at baseline and throughout follow-up; n = 103 had incident MCI and n = 81 had incident AD. Proteomics were conducted on banked plasma samples from a previously generated algorithm. The proteomic profile was highly accurate in predicting incident MCI (area under the curve [AUC] = 0.92) and incident AD (AUC = 0.88). For MCI risk, the support vector machine (SVM)-based high/low cut-point yielded an adjusted hazard ratio (HR) = 6.46 ( The current results provide support for our blood-based proteomic profile for predicting risk for MCI and AD among adults with DS.
Identifiants
pubmed: 32490140
doi: 10.1002/dad2.12033
pii: DAD212033
pmc: PMC7241058
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12033Subventions
Organisme : NIA NIH HHS
ID : P30 AG066462
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG008702
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of the Alzheimer's Association.
Déclaration de conflit d'intérêts
Sid E. O'Bryant has patents and patents pending regarding blood‐biomarkers for precision medicine in neurodegenerative diseases and served on an Advisory Board to Roche Diagnostics. No other authors have conflicts of interest to disclose.
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