Transcranial stimulation in frontotemporal dementia: A randomized, double-blind, sham-controlled trial.
clinical trial
frontotemporal dementia
granulin
presymptomatic
short interval intracortical inhibition
transcranial direct current stimulation
transcranial magnetic stimulation
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
03
2020
accepted:
06
04
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
4
6
2020
Statut:
epublish
Résumé
Frontotemporal dementia (FTD) is a progressive disease for which no curative treatment is currently available. We aimed to determine whether transcranial direct current stimulation (tDCS) can modulate intracortical connectivity and improve cognition in symptomatic FTD patients and presymptomatic FTD subjects. We performed a double-blind, randomized, sham-controlled trial with anodal tDCS or sham stimulation over the left prefrontal cortex in 70 participants (15 presymptomatic and 55 symptomatic FTD). We observed a significant increase of intracortical connectivity (short interval intracortical inhibition and facilitation) and improvement in clinical scores and behavioral disturbances in both symptomatic FTD patients and presymptomatic carriers after real tDCS but not after sham stimulation. A 2-weeks' treatment with anodal left prefrontal tDCS improves symptoms and restores intracortical inhibitory and excitatory circuits in both symptomatic FTD patients and presymptomatic carriers. tDCS might represent a promising future therapeutic and rehabilitative approach in patients with FTD.
Identifiants
pubmed: 32490143
doi: 10.1002/trc2.12033
pii: TRC212033
pmc: PMC7253155
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12033Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
A. Benussi, V. Dell'Era, M. Cosseddu,V. Cantoni, M.S. Cotelli, M. Cotelli, R. Manenti, L. Benussi, C. Brattini, A. Alberici, B. Borroni, report no disclosures relevant to the manuscript.
Références
Brain Stimul. 2020 Mar - Apr;13(2):386-392
pubmed: 31787557
J Physiol. 1996 Nov 1;496 ( Pt 3):873-81
pubmed: 8930851
Alzheimers Dement. 2015 Sep;11(9):1032-40
pubmed: 25449530
Neurology. 2017 Aug 15;89(7):665-672
pubmed: 28747446
Neurology. 2011 Mar 15;76(11):1006-14
pubmed: 21325651
Alzheimers Res Ther. 2018 Sep 18;10(1):94
pubmed: 30227895
Front Neurosci. 2019 Mar 29;13:304
pubmed: 30983965
Sci Rep. 2016 Feb 24;6:22180
pubmed: 26908001
Brain. 2018 May 1;141(5):1263-1285
pubmed: 29373632
Nat Neurosci. 2013 Jul;16(7):838-44
pubmed: 23799477
Lancet Neurol. 2015 Mar;14(3):253-62
pubmed: 25662776
Cereb Cortex. 2019 Feb 1;29(2):657-665
pubmed: 29329367
Brain Topogr. 2018 May;31(3):488-497
pubmed: 29256051
J Neurol Neurosurg Psychiatry. 1994 Apr;57(4):416-8
pubmed: 8163988
Brain Topogr. 2016 Sep;29(5):738-51
pubmed: 27194245
Ann Neurol. 2016 Sep;80(3):472-6
pubmed: 27438089
Ann Neurol. 2020 Mar;87(3):394-404
pubmed: 31925823
Ann Neurol. 2016 Nov;80(5):693-707
pubmed: 27553723
Brain. 2011 Sep;134(Pt 9):2456-77
pubmed: 21810890
Nat Commun. 2016 Mar 22;7:11100
pubmed: 27000523
Clin Neurophysiol. 2015 Oct;126(10):1847-68
pubmed: 25534482
Neurobiol Aging. 2019 Apr;76:133-140
pubmed: 30711676
Amyotroph Lateral Scler Frontotemporal Degener. 2015 Mar;16(1-2):86-91
pubmed: 25352065
Cortex. 2015 Aug;69:175-85
pubmed: 26073148
Brain Stimul. 2018 Mar - Apr;11(2):366-373
pubmed: 29195744
Neurodegener Dis. 2014;13(4):224-9
pubmed: 24029600
Clin Neurophysiol. 2015 Jun;126(6):1071-1107
pubmed: 25797650
Electroencephalogr Clin Neurophysiol. 1992 Dec;85(6):355-64
pubmed: 1282453
Neuron. 2010 Apr 29;66(2):198-204
pubmed: 20434997
Nat Rev Neurol. 2013 May;9(5):241-2
pubmed: 23609620
Electroencephalogr Clin Neurophysiol. 1993 Aug;89(4):227-34
pubmed: 7688685
J Physiol. 1993 Nov;471:501-19
pubmed: 8120818
Clin Neurophysiol. 2017 Jan;128(1):56-92
pubmed: 27866120
J Alzheimers Dis. 2020;73(3):1133-1142
pubmed: 31884481
J Alzheimers Dis. 2014;39(4):799-808
pubmed: 24296814
NeuroRehabilitation. 2019;45(3):369-378
pubmed: 31796701
Alzheimers Dement (N Y). 2018 Sep 05;4:461-472
pubmed: 30258975