Mitochondrial ion channels as targets for cardioprotection.
Mitochondria
acute ischaemia/reperfusion injury
cardioprotection
mitochondrial permeability transition pore
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
17
01
2020
revised:
31
03
2020
accepted:
12
04
2020
pubmed:
4
6
2020
medline:
29
4
2021
entrez:
4
6
2020
Statut:
ppublish
Résumé
Acute myocardial infarction (AMI) and the heart failure (HF) that often result remain the leading causes of death and disability worldwide. As such, new therapeutic targets need to be discovered to protect the myocardium against acute ischaemia/reperfusion (I/R) injury in order to reduce myocardial infarct (MI) size, preserve left ventricular function and prevent the onset of HF. Mitochondrial dysfunction during acute I/R injury is a critical determinant of cell death following AMI, and therefore, ion channels in the inner mitochondrial membrane, which are known to influence cell death and survival, provide potential therapeutic targets for cardioprotection. In this article, we review the role of mitochondrial ion channels, which are known to modulate susceptibility to acute myocardial I/R injury, and we explore their potential roles as therapeutic targets for reducing MI size and preventing HF following AMI.
Identifiants
pubmed: 32490600
doi: 10.1111/jcmm.15341
pmc: PMC7339171
doi:
Substances chimiques
Calcium Channels
0
Cardiotonic Agents
0
Ion Channels
0
mitochondrial calcium uniporter
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7102-7114Subventions
Organisme : Swiss National Science Foundation
ID : 310030E_176050
Pays : Switzerland
Organisme : British Heart Foundation
ID : FS/13/41/30368
Pays : United Kingdom
Organisme : Swiss National Science Foundation
ID : IZCOZ0_189878
Pays : Switzerland
Organisme : Medical Research Council
ID : MR/J003530/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CS/14/3/31002
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
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