Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women's Health Across the Nation.
Age Factors
Alkanesulfonic Acids
/ blood
Caprylates
/ blood
Cohort Studies
Cross-Sectional Studies
Environmental Exposure
/ statistics & numerical data
Environmental Pollutants
/ blood
Female
Fluorocarbons
/ blood
Humans
Incidence
Menopause
/ blood
Middle Aged
Time Factors
United States
/ epidemiology
Women's Health
endocrine-disrupting chemicals
midlife women
natural menopause
per- and polyfluoroalkyl substances (PFAS)
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
03
03
2020
accepted:
20
05
2020
pubmed:
4
6
2020
medline:
24
2
2021
entrez:
4
6
2020
Statut:
ppublish
Résumé
Previous epidemiologic studies of per- and polyfluoroalkyl substances (PFASs) and menopausal timing conducted in cross-sectional settings were limited by reverse causation because PFAS serum concentrations increase after menopause. To investigate associations between perfluoroalkyl substances and incident natural menopause. A prospective cohort of midlife women, the Study of Women's Health Across the Nation, 1999-2017. 1120 multiracial/ethnic premenopausal women aged 45-56 years. Serum concentrations of perfluoroalkyls were quantified by high-performance liquid chromatography isotope dilution tandem mass spectrometry. Natural menopause was defined as the bleeding episode prior to at least 12 months of amenorrhea not due to surgery or hormone use. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Participants contributed 5466 person-years of follow-up, and 578 had incident natural menopause. Compared with the lowest tertile, women at the highest tertile of baseline serum concentrations had adjusted HR for natural menopause of 1.26 (95% CI: 1.02-1.57) for n-perfluorooctane sulfonic acid (n-PFOS) (Ptrend = .03), 1.27 (95% CI: 1.01-1.59) for branched-PFOS (Ptrend = .03), and 1.31 (95% CI: 1.04-1.65) for n-perfluorooctanoic acid (Ptrend = .01). Women were classified into four clusters based on their overall PFAS concentrations as mixtures: low, low-medium, medium-high, and high. Compared with the low cluster, the high cluster had a HR of 1.63 (95% CI: 1.08-2.45), which is equivalent to 2.0 years earlier median time to natural menopause. This study suggests that select PFAS serum concentrations are associated with earlier natural menopause, a risk factor for adverse health outcomes in later life.
Identifiants
pubmed: 32491182
pii: 5848088
doi: 10.1210/clinem/dgaa303
pmc: PMC7418447
pii:
doi:
Substances chimiques
Alkanesulfonic Acids
0
Caprylates
0
Environmental Pollutants
0
Fluorocarbons
0
perfluorooctanoic acid
947VD76D3L
perfluorooctane sulfonic acid
9H2MAI21CL
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : U01 AG012554
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024131
Pays : United States
Organisme : ACL HHS
ID : T42OH008455
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG012535
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG012553
Pays : United States
Organisme : NINR NIH HHS
ID : U01 NR004061
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG012539
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES026578
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG012546
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG063720
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG012495
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG012505
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG012531
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES026964
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG017719
Pays : United States
Informations de copyright
© Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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