Harmonization of Quantitative Parenchymal Enhancement in T
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
09
03
2020
revised:
19
05
2020
accepted:
20
05
2020
pubmed:
4
6
2020
medline:
15
5
2021
entrez:
4
6
2020
Statut:
ppublish
Résumé
Differences in imaging parameters influence computer-extracted parenchymal enhancement measures from breast MRI. To investigate the effect of differences in dynamic contrast-enhanced MRI acquisition parameter settings on quantitative parenchymal enhancement of the breast, and to evaluate harmonization of contrast-enhancement values with respect to flip angle and repetition time. Retrospective. We modeled parenchymal enhancement using simulations, a phantom, and two cohorts (N = 398 and N = 302) from independent cancer centers. 1.5T dynamic contrast-enhanced T We assessed harmonization of parenchymal enhancement in simulations and phantom by varying the MR parameters that influence the amount of T Paired Wilcoxon signed-rank-test of bootstrapped kernel density estimations. Before harmonization, simulated enhancement values had a median (IQR) of 0.46 (0.34-0.49). After harmonization, the IQR was reduced: median (IQR): 0.44 (0.44-0.45). In the phantom, the IQR also decreased, median (IQR): 0.96 (0.59-1.22) before harmonization, 0.96 (0.91-1.02) after harmonization. Harmonization yielded significantly (P < 0.001) better overlap in parenchymal enhancement between the cohorts: median (IQR) was 0.46 (0.37-0.58) for cohort 1 vs. 0.37 (0.30-0.44) for cohort 2 before harmonization (57% overlap); and 0.35 (0.28-0.43) vs. .0.37 (0.30-0.44) after harmonization (85% overlap). The proposed practical harmonization method enables an accurate comparison between patients scanned with differences in imaging parameters. 3 TECHNICAL EFFICACY STAGE: 4.
Sections du résumé
BACKGROUND
Differences in imaging parameters influence computer-extracted parenchymal enhancement measures from breast MRI.
PURPOSE
To investigate the effect of differences in dynamic contrast-enhanced MRI acquisition parameter settings on quantitative parenchymal enhancement of the breast, and to evaluate harmonization of contrast-enhancement values with respect to flip angle and repetition time.
STUDY TYPE
Retrospective.
PHANTOM/POPULATIONS
We modeled parenchymal enhancement using simulations, a phantom, and two cohorts (N = 398 and N = 302) from independent cancer centers.
SEQUENCE FIELD/STRENGTH
1.5T dynamic contrast-enhanced T
ASSESSMENT
We assessed harmonization of parenchymal enhancement in simulations and phantom by varying the MR parameters that influence the amount of T
STATISTICAL TESTS
Paired Wilcoxon signed-rank-test of bootstrapped kernel density estimations.
RESULTS
Before harmonization, simulated enhancement values had a median (IQR) of 0.46 (0.34-0.49). After harmonization, the IQR was reduced: median (IQR): 0.44 (0.44-0.45). In the phantom, the IQR also decreased, median (IQR): 0.96 (0.59-1.22) before harmonization, 0.96 (0.91-1.02) after harmonization. Harmonization yielded significantly (P < 0.001) better overlap in parenchymal enhancement between the cohorts: median (IQR) was 0.46 (0.37-0.58) for cohort 1 vs. 0.37 (0.30-0.44) for cohort 2 before harmonization (57% overlap); and 0.35 (0.28-0.43) vs. .0.37 (0.30-0.44) after harmonization (85% overlap).
DATA CONCLUSION
The proposed practical harmonization method enables an accurate comparison between patients scanned with differences in imaging parameters.
LEVEL OF EVIDENCE
3 TECHNICAL EFFICACY STAGE: 4.
Identifiants
pubmed: 32491246
doi: 10.1002/jmri.27244
pmc: PMC7687185
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1374-1382Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2020 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
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