Protein tyrosine phosphatase-α amplifies transforming growth factor-β-dependent profibrotic signaling in lung fibroblasts.

Animals Bleomycin / pharmacology Cells, Cultured Epithelial Cells / drug effects Fibroblasts / drug effects Idiopathic Pulmonary Fibrosis / chemically induced Lung / drug effects Mice Mice, Inbred C57BL Phosphorylation / drug effects Receptor-Like Protein Tyrosine Phosphatases, Class 4 / metabolism Signal Transduction / drug effects Transforming Growth Factor beta / metabolism
IPF TGF-β fibroblast protein tyrosine phosphatase-α pulmonary fibrosis

Journal

American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229

Informations de publication

Date de publication:
01 08 2020
Historique:
pubmed: 4 6 2020
medline: 21 11 2020
entrez: 4 6 2020
Statut: ppublish

Résumé

Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal, fibrosing lung disease for which treatment remains suboptimal. Fibrogenic cytokines, including transforming growth factor-β (TGF-β), are central to its pathogenesis. Protein tyrosine phosphatase-α (PTPα) has emerged as a key regulator of fibrogenic signaling in fibroblasts. We have reported that mice globally deficient in PTPα (

Identifiants

DOI: 10.1152/ajplung.00235.2019 PMID: 32491951 PMC: PMC7473933
pubmed: 32491951
doi: 10.1152/ajplung.00235.2019
pmc: PMC7473933
doi:

Substances chimiques

Transforming Growth Factor beta 0
Bleomycin 11056-06-7
Ptpra protein, mouse EC 3.1.3.48
Receptor-Like Protein Tyrosine Phosphatases, Class 4 EC 3.1.3.48

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

L294-L311

Subventions

Organisme : BLRD VA
ID : IK6 BX005240
Pays : United States
Organisme : CIHR
ID : MOP-106625
Pays : Canada
Organisme : NIH NHLBI
ID : HL140595
Pays : International
Organisme : NCATS NIH HHS
ID : KL2 TR002534
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132950
Pays : United States
Organisme : BLRD VA
ID : I01 BX002025
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147920
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES023932
Pays : United States
Organisme : VA
ID : BX002401
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL135279
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL103772
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131608
Pays : United States
Organisme : NIH NHLBI
ID : HL132950
Pays : International
Organisme : NIH NHLBI
ID : 114754
Pays : International
Organisme : NIDDK NIH HHS
ID : R01 DK119212
Pays : United States
Organisme : CIHR
ID : MOP-384254
Pays : Canada
Organisme : NIH NHLBI
ID : K08 HL135279-01A1
Pays : International
Organisme : NIDDK NIH HHS
ID : P30 DK114809
Pays : United States
Organisme : VA
ID : I01BX003471
Pays : United States
Organisme : BLRD VA
ID : I01 BX003471
Pays : United States

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Auteurs

Yael Aschner (Y)

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.

Meghan Nelson (M)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.

Matthew Brenner (M)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.

Helen Roybal (H)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.

Keriann Beke (K)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.

Carly Meador (C)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.

Daniel Foster (D)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.

Kelly A Correll (KA)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.

Paul R Reynolds (PR)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.

Kelsey Anderson (K)

Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado.

Elizabeth F Redente (EF)

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.
Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado.
Veterans Affairs Eastern Colorado Heath Care System, Denver, Colorado.

Jennifer Matsuda (J)

Department of Biomedical Research, National Jewish Health, Denver, Colorado.

David W H Riches (DWH)

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.
Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado.
Veterans Affairs Eastern Colorado Heath Care System, Denver, Colorado.
Department of Immunology and Microbiology, University of Colorado, Aurora, Colorado.
ORCID: 0000-0002-9587-3335

Steve D Groshong (SD)

Division of Pathology, Department of Medicine, National Jewish Health, Denver, Colorado.

Ambra Pozzi (A)

Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Veterans Affairs Medical Center, Nashville, Tennessee.

Jan Sap (J)

Epigenetics and Cell Fate, Université Paris, Paris, France.

Qin Wang (Q)

Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Dhaarmini Rajshankar (D)

Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Christopher A G McCulloch (CAG)

Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Rachel L Zemans (RL)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

Gregory P Downey (GP)

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Department of Pediatrics, National Jewish Health, Denver, Colorado.
Department of Biomedical Research, National Jewish Health, Denver, Colorado.
Department of Immunology and Microbiology, University of Colorado, Aurora, Colorado.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Glycopeptides › Bléomycine › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Cellules › Cellules cultivées › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Cellules › Cellules épithéliales › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Pneumopathies interstitielles › Fibrose pulmonaire idiopathique › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Appareil respiratoire › Poumon › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Métabolisme › Phosphorylation › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Receptor-Like Protein Tyrosine Phosphatases, Class 4 › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Protein tyrosine phosphatase-α amplifies...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Protein tyrosine phosphatase-α amplifies...