Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening.

Action Potentials / physiology Alternative Splicing / genetics Animals Calcium-Calmodulin-Dependent Protein Kinase Type 1 / metabolism Calcium-Calmodulin-Dependent Protein Kinases / metabolism Female HEK293 Cells Homeostasis / physiology Humans Large-Conductance Calcium-Activated Potassium Channels / genetics Long-Term Potentiation / physiology Male Mice Mice, Inbred C57BL Nerve Tissue Proteins / metabolism Neuro-Oncological Ventral Antigen Neuronal Plasticity / physiology Neurons / metabolism RNA-Binding Proteins / metabolism Rats Rats, Sprague-Dawley Signal Transduction Synapses / metabolism Synaptic Transmission / physiology
Alternative splicing BK channel CaM kinase Nova-2 action potential duration chronic inactivity homeostasis synaptic activity

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
25 06 2020
Historique:
received: 24 04 2019
revised: 28 01 2020
accepted: 04 05 2020
pubmed: 4 6 2020
medline: 22 1 2021
entrez: 4 6 2020
Statut: ppublish

Résumé

Homeostasis of neural firing properties is important in stabilizing neuronal circuitry, but how such plasticity might depend on alternative splicing is not known. Here we report that chronic inactivity homeostatically increases action potential duration by changing alternative splicing of BK channels; this requires nuclear export of the splicing factor Nova-2. Inactivity and Nova-2 relocation were connected by a novel synapto-nuclear signaling pathway that surprisingly invoked mechanisms akin to Hebbian plasticity: Ca

Identifiants

DOI: 10.1016/j.cell.2020.05.013 PMID: 32492405 PMC: PMC9310388
pubmed: 32492405
pii: S0092-8674(20)30575-4
doi: 10.1016/j.cell.2020.05.013
pmc: PMC9310388
mid: NIHMS1599436
pii:
doi:

Substances chimiques

Large-Conductance Calcium-Activated Potassium Channels 0
NOVA2 protein, human 0
Nerve Tissue Proteins 0
Neuro-Oncological Ventral Antigen 0
RNA-Binding Proteins 0
Calcium-Calmodulin-Dependent Protein Kinase Type 1 EC 2.7.11.17
Calcium-Calmodulin-Dependent Protein Kinases EC 2.7.11.17

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1547-1565.e15

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM058234
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH071739
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA040484
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH071739
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS024067
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Boxing Li (B)

Neuroscience Program, Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine and The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510810, China; Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA. Electronic address: liboxing@mail.sysu.edu.cn.

Benjamin S Suutari (BS)

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA.

Simón(e) D. Sun (SD)

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA.

Zhengyi Luo (Z)

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510120, China.

Chuanchuan Wei (C)

Neuroscience Program, Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine and The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510810, China.

Nicolas Chenouard (N)

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA.

Nataniel J Mandelberg (NJ)

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA.

Guoan Zhang (G)

Department of Biochemistry and Molecular Pharmacology and Skirball Institute, NYU Grossman Medical Center, New York, NY 10016, USA.

Brie Wamsley (B)

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Stanley Center for Psychiatric Research, The Broad Institute, Cambridge, MA 02142, USA.

Guoling Tian (G)

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA.

Sandrine Sanchez (S)

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA.

Sikun You (S)

Neuroscience Program, Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine and The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510810, China.

Lianyan Huang (L)

Neuroscience Program, Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine and The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510810, China.

Thomas A Neubert (TA)

Department of Biochemistry and Molecular Pharmacology and Skirball Institute, NYU Grossman Medical Center, New York, NY 10016, USA.

Gordon Fishell (G)

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Stanley Center for Psychiatric Research, The Broad Institute, Cambridge, MA 02142, USA.

Richard W Tsien (RW)

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address: richard.tsien@nyulangone.org.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Épissage alternatif › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Eucaryotes › Animaux › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Calcium-Calmodulin-Dependent Protein Kinases › Calcium-Calmodulin-Dependent Protein Kinase Type 1 › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Calcium-Calmodulin-Dependent Protein Kinases › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques calcium-dépendants › Canaux potassiques calcium-dépendants de grande conductance › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Potentialisation à long terme › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Neuro-oncological ventral antigen › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Cellules › Neurones › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Neuronal Inactivity Co-opts LTP Machinery to...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Neuronal Inactivity Co-opts LTP Machinery to...