Effect of Omega-3 Polyunsaturated Fatty Acids Treatment on Lipid Pattern of HIV Patients: A Meta-Analysis of Randomized Clinical Trials.
HIV
Omega-3 polyunsaturated fatty acids
high-density lipoprotein cholesterol
meta-analysis
triglycerides
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
01 Jun 2020
01 Jun 2020
Historique:
received:
08
05
2020
revised:
20
05
2020
accepted:
25
05
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
18
3
2021
Statut:
epublish
Résumé
Even though omega-3 polyunsaturated fatty acids (PUFAs) seem to be effective in the treatment of human immunodeficiency virus (HIV)-associated dyslipidemia, their impact is still debated. For this reason, our aim was to perform a meta-analysis of the clinical evidence available to date. A systematic literature search was conducted in order to identify published clinical trials assessing the effect of PUFAs treatment on serum lipoproteins, and its safety profile. The effect sizes for lipid changes were expressed as mean difference (MD) and 95% confidence interval (CI). For safety analysis, odd ratios and the 95% CI were calculated with the Mantel-Haenszel method. Data were pooled from nine clinical studies comprising overall 578 HIV-affected subjects. Meta-analysis of the data suggested that omega-3 PUFAs significantly reduced triglycerides (TG) (MD = -1.04, 95% CI: -1.5, -0.58 mmol/L,
Identifiants
pubmed: 32492789
pii: md18060292
doi: 10.3390/md18060292
pmc: PMC7345035
pii:
doi:
Substances chimiques
Cholesterol, HDL
0
Cholesterol, LDL
0
Fatty Acids, Omega-3
0
Triglycerides
0
Eicosapentaenoic Acid
AAN7QOV9EA
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
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