Dietary β-Carotene Rescues Vitamin A Deficiency and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice.
adipose tissue
atherogenesis
liver
vitamin A
β-carotene
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
01 Jun 2020
01 Jun 2020
Historique:
received:
31
03
2020
revised:
25
05
2020
accepted:
28
05
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
23
2
2021
Statut:
epublish
Résumé
Vitamin A deficiency (VAD) is a major health problem, especially in developing countries. In this study, we investigated the effect of VAD from weaning to adulthood in apoE-/- mice. Three-week-old male mice were allocated into four diet groups: I. VAD II. VAD+vitamin A (VA), 1500 IU retinyl-palmitate; III. VAD+β-carotene (BC), 6 g/kg feed, containing 50% all-trans and 50% 9-cis BC. IV. VAD with BC and VA (BC+VA). After 13 weeks, we assessed the size of atherosclerotic plaques and measured VA in tissues and BC in plasma and tissues. VAD resulted in diminished hepatic VA levels and undetectable brain VA levels compared to the other groups. BC completely replenished VA levels in the liver, and BC+VA led to a two-fold elevation of hepatic VA accumulation. In adipose tissue, mice fed BC+VA accumulated only 13% BC compared to mice fed BC alone. Atherosclerotic lesion area of BC group was 73% lower compared to VAD group (
Identifiants
pubmed: 32492795
pii: nu12061625
doi: 10.3390/nu12061625
pmc: PMC7352614
pii:
doi:
Substances chimiques
Apolipoproteins E
0
beta Carotene
01YAE03M7J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
A.S. and D.H. are supported by Nikken Sohonsha Corporation, Japan. The company had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. N.B.T. Israel provided support in the form of a salary for author A.B.-A, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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