When Oxidative Stress Meets Epigenetics: Implications in Cancer Development.
cancer
cancer therapy
chemoresistance
epigenetics
miR7/MAFG/Nrf2 axe
oxidative stress
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
01 Jun 2020
01 Jun 2020
Historique:
received:
04
05
2020
revised:
28
05
2020
accepted:
29
05
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
5
6
2020
Statut:
epublish
Résumé
Cancer is one of the leading causes of death worldwide and it can affect any part of the organism. It arises as a consequence of the genetic and epigenetic changes that lead to the uncontrolled growth of the cells. The epigenetic machinery can regulate gene expression without altering the DNA sequence, and it comprises methylation of the DNA, histones modifications, and non-coding RNAs. Alterations of these gene-expression regulatory elements can be produced by an imbalance of the intracellular environment, such as the one derived by oxidative stress, to promote cancer development, progression, and resistance to chemotherapeutic treatments. Here we review the current literature on the effect of oxidative stress in the epigenetic machinery, especially over the largely unknown ncRNAs and its consequences toward cancer development and progression.
Identifiants
pubmed: 32492865
pii: antiox9060468
doi: 10.3390/antiox9060468
pmc: PMC7346131
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI15/00186 and PI18/00050
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : RTC-2016-5314-1
Organisme : European Social Fund
ID : Una Manera de Hacer Europa
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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